Homo sapiens exhibit a distinct pattern of CNV genes regulation

• Verfasst von: Dweep, Harsh [VerfasserIn]
• Verfasst von: Gretz, Norbert [VerfasserIn]
• Titel: Homo sapiens exhibit a distinct pattern of CNV genes regulation
• Titelzusatz: an important role of miRNAs and SNPs in expression plasticity
• Verf.angabe: Harsh Dweep, Nada Kubikova, Norbert Gretz, Konstantinos Voskarides and Kyriacos Felekkis
• E-Jahr: 2015
• Jahr: 16 July 2015
• Umfang: 10 S.
• Fussnoten: Gesehen am 19.01.2018
• Titel Quelle: Enthalten in: Scientific reports
• Ort Quelle: [London] : Springer Nature, 2011
• Jahr Quelle: 2015
• Band/Heft Quelle: 5(2015) Artikel-Nummer 12163, 10 Seiten
• ISSN Quelle: 2045-2322
• DOI: doi:10.1038/srep12163
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1567362680

Abstract

Gene expression regulation is a complex and highly organized process involving a variety of genomic factors. It is widely accepted that differences in gene expression can contribute to the phenotypic variability between species, and that their interpretation can aid in the understanding of the physiologic variability. CNVs and miRNAs are two major players in the regulation of expression plasticity and may be responsible for the unique phenotypic characteristics observed in different lineages. We have previously demonstrated that a close interaction between these two genomic elements may have contributed to the regulation of gene expression during evolution. This work presents the molecular interactions between CNV and non CNV genes with miRNAs and other genomic elements in eight different species. A comprehensive analysis of these interactions indicates a unique nature of human CNV genes regulation as compared to other species. By using genes with short 3′ UTR that abolish the “canonical” miRNA-dependent regulation, as a model, we demonstrate a distinct and tight regulation of human genes that might explain some of the unique features of human physiology. In addition, comparison of gene expression regulation between species indicated that there is a significant difference between humans and mice possibly questioning the effectiveness of the latest as experimental models of human diseases.