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Verfasst von:Frederiksen, Kristian Steen [VerfasserIn]   i
 Bäzner, Hansjörg [VerfasserIn]   i
Titel:Physical activity in the elderly is associated with improved executive function and processing speed
Titelzusatz:the LADIS Study
Verf.angabe:Kristian Steen Frederiksen, Ana Verdelho, Sofia Madureira, Hansjörg Bäzner, John T. O'Brien, Franz Fazekas, Philip Scheltens, Reinhold Schmidt, Anders Wallin, Lars-Olof Wahlund, Timo Erkinjunttii, Anna Poggesi, Leonardo Pantoni, Domenico Inzitari, Gunhild Waldemar and on behalf of the LADIS Study
E-Jahr:2015
Jahr:03 November 2014
Jahr des Originals:2014
Umfang:7 S.
Fussnoten:Gesehen am 23.01.2018
Titel Quelle:Enthalten in: International journal of geriatric psychiatry
Ort Quelle:Chichester [u.a.] : Wiley, 1986
Jahr Quelle:2015
Band/Heft Quelle:30(2015), 7, Seite 744-750
ISSN Quelle:1099-1166
Abstract:Objectives: Physical activity reduces the risk of cognitive decline but may affect cognitive domains differently. We examined whether physical activity modifies processing speed, executive function and memory in a population of non-dementia elderly subjects with age-related white matter changes (ARWMC). Methods: Data from the Leukoaraiosis And DISability (LADIS) study, a multicenter, European prospective cohort study aimed at examining the role of ARWMC in transition to disability, was used. Subjects in the LADIS study were clinically assessed yearly for 3 years including MRI at baseline and 3-year follow-up. Physical activity was assessed at baseline, and cognitive compound scores at baseline and 3-year assessment were used. Results: Two-hundred-eighty-two subjects (age, y (mean (SD)): 73.1 (±5.1); gender (f/m): 164/118); MMSE (mean (SD)): 28.3 (±1.7)) who had not progressed to MCI or dementia, were included. Multiple variable linear regression analysis with baseline MMSE, education, gender, age, stroke, diabetes and ARWMC rating as covariates revealed that physical activity was associated with better scores at baseline and 3-year follow-up for executive function (baseline: β: 0.39, 95% CI: 0.13-0.90, p = 0.008; follow-up: β: 0.24, 95% CI: 0.10-0.38, p = 0.001) and processing speed (baseline: β: 0.48, 95% CI: 0.14-0.89, p = 0.005; follow-up: β: 0.15, 95% CI: 0.02-0.29, p = 0.02) but not memory. When including baseline cognitive score as a covariate in the analysis of 3-year follow-up scores, executive function remained significant (β: 0.11, 95% CI: 0-0.22, p = 0.04). Conclusion: Our findings confirm previous findings of a positive effect of physical activity on cognitive functions in elderly subjects, and further extends these by showing that the association is also present in patients with ARWMC.
DOI:doi:10.1002/gps.4220
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1002/gps.4220
 Volltext: http://onlinelibrary.wiley.com.ezproxy.medma.uni-heidelberg.de/doi/10.1002/gps.4220/abstract
 DOI: https://doi.org/10.1002/gps.4220
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:age-related white matter changes
 cognitive
 executive function
 memory
 physical activity
 processing speed
K10plus-PPN:156753502X
Verknüpfungen:→ Zeitschrift

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