Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Klemke, Claus-Detlev [VerfasserIn]   i
 Booken, Nina [VerfasserIn]   i
 Weiß, Christel [VerfasserIn]   i
 Nicolay, Jan Peter [VerfasserIn]   i
 Goerdt, Sergij [VerfasserIn]   i
 Felcht, Moritz [VerfasserIn]   i
 Géraud, Cyrill [VerfasserIn]   i
Titel:Histopathological and immunophenotypical criteria for the diagnosis of Sézary syndrome in differentiation from other erythrodermic skin diseases
Titelzusatz:a European Organisation for Research and Treatment of Cancer (EORTC) Cutaneous Lymphoma Task Force Study of 97 cases
Verf.angabe:C.D. Klemke, N. Booken, C. Weiss, J.P. Nicolay, S. Goerdt, M. Felcht, C. Géraud, W. Kempf, C. Assaf, N. Ortonne, M. Battistella, M. Bagot, R. Knobler, P. Quaglino, B. Arheiliger, M. Santucci, P. Jansen, M.H. Vermeer and R. Willemze
E-Jahr:2015
Jahr:July 2015
Umfang:13 S.
Fussnoten:Gesehen am 24.01.2018
Titel Quelle:Enthalten in: British journal of dermatology
Ort Quelle:Oxford : Oxford University Press, 1892
Jahr Quelle:2015
Band/Heft Quelle:173(2015), 1, Seite 93-105
ISSN Quelle:1365-2133
Abstract:Background: Patients with erythrodermic disease are a diagnostic challenge regarding the clinical and histological differential diagnosis. Objectives: To evaluate histopathological and immunohistochemical diagnostic markers for Sézary syndrome. Methods: Ninety-seven erythrodermic cases [Sézary syndrome (SS), n = 57; erythrodermic inflammatory dermatoses (EIDs), n = 40] were collected by the EORTC Cutaneous Lymphoma Task Force histopathology group. Evaluation criteria were (i) epidermal and dermal changes; (ii) morphology of the infiltrate; (iii) immunohistochemical analysis of marker loss (CD2, CD3, CD4, CD5 and CD7); (iv) bystander infiltrate by staining for CD8, FOXP3 and CD25; and (v) expression of Ki-67, CD30, PD-1 and MUM-1. Results: The workshop panel made a correct diagnosis of SS in 51% of cases (cutaneous T-cell lymphoma 81%) and of EID in 80% without clinical or laboratory data. Histology revealed a significantly increased degree of epidermotropism (P < 0·001) and more intraepidermal atypical lymphocytes (P = 0·0014) in SS biopsies compared with EID. Pautrier microabscesses were seen only in SS (23%) and not in EID (P = 0·0012). SS showed significantly more dermal cerebriform and blastic lymphocytes than EID. Immunohistochemistry revealed a significant loss of CD7 expression (< 50%) in 33 of 51 (65%) cases of SS compared with two of 35 (6%) EID (P < 0·001). The lymphocytic infiltrate in SS skin samples was found significantly to express PD-1 (P = 0·0053), MUM-1 (P = 0·0017) and Ki-67 (P < 0·001), and showed less infiltration of CD8+ lymphocytes (P < 0·001). A multivariate analysis identified CD7 loss, increased numbers of small cerebriform lymphocytes, low numbers of CD8+ lymphocytes and increased proliferation (Ki-67+ lymphocytes) as the strongest indicators for the diagnosis of SS. Conclusions: A number of different histological and immunophenotypical criteria are required to differentiate between SS and EIDs.
DOI:doi:10.1111/bjd.13832
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1111/bjd.13832
 Volltext: http://onlinelibrary.wiley.com/doi/10.1111/bjd.13832/abstract
 DOI: https://doi.org/10.1111/bjd.13832
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1567560164
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68212984   QR-Code
zum Seitenanfang