Soluble klotho and mortality

• Verfasst von: Brandenburg, Vincent [VerfasserIn]
• Verfasst von: Kleber, Marcus E. [VerfasserIn]
• Verfasst von: Delgado Gonzales de Kleber, Graciela [VerfasserIn]
• Verfasst von: Grammer, Tanja B. [VerfasserIn]
• Verfasst von: März, Winfried [VerfasserIn]
• Titel: Soluble klotho and mortality
• Titelzusatz: the Ludwigshafen Risk and Cardiovascular Health Study
• Verf.angabe: Vincent M. Brandenburg, Marcus E. Kleber, Marc G. Vervloet, Tobias E. Larsson, Andreas Tomaschitz, Stefan Pilz, Tatjana Stojakovic, Graciela Delgado, Tanja B. Grammer, Nikolaus Marx, Winfried März, Hubert Scharnagl
• E-Jahr: 2015
• Jahr: October 2015
• Umfang: 7 S.
• Fussnoten: Gesehen am 25.01.2018
• Titel Quelle: Enthalten in: Atherosclerosis
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1970
• Jahr Quelle: 2015
• Band/Heft Quelle: 242(2015), 2, Seite 483-489
• ISSN Quelle: 1879-1484
• DOI: doi:10.1016/j.atherosclerosis.2015.08.017
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Coronary artery disease
• Sach-SW: Cardiovascular events
• Sach-SW: Coronary angiography
• Sach-SW: Fibroblast growth factor 23, FGF23
• Sach-SW: Outcome
• K10plus-PPN: 1567607098

Abstract

Background: Experimental evidence suggests that soluble klotho (s-klotho), a co-receptor for fibroblast growth factor 23 (FGF23), may modulate cardiovascular risk through multiple mechanisms. However, the predictive value of s-klotho in patients remains unclear. Therefore, the present study examined in a large cohort of patients referred for coronary angiography whether s-klotho is associated with cardiovascular and total mortality. Methods: The longitudinal associations between baseline s-klotho and FGF23 concentrations and mortality were evaluated in 2948 participants of the Ludwigshafen Risk and Cardiovascular Health Study (LURIC), referred for coronary angiography. Results: Mean age of participants was: 63 ± 10 years. Patients with diabetes mellitus (n = 1136) had elevated s-klotho: [440 (430-449) versus 414 (406-421) pg/mL, p < 0.001]. S-klotho decreased in parallel to glomerular filtration rate (GFR) and increased in parallel to FGF23. During a median follow-up of 9.9 years, 874 deaths (30%) occurred, 539 (18%) of which were cardiovascular. After adjustment for cardiovascular risk factors, the hazard ratios in the fourth quartile compared to the first quartile of s-klotho were 1.14 (95%CI, 0.94-1.38; p = 0.187) for all-cause mortality and 1.03 (95%CI, 0.80-1.31; p = 0.845) for cardiovascular mortality. Excess mortality prediction by high levels of baseline FGF23 was not modified by adjustment for baseline s-klotho levels. Conclusions: Klotho does not add predictive power to cardiovascular and mortality risk assessment in patients with normal renal function.