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| Verfasst von: | Selt, Florian [VerfasserIn]  |
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| | Korshunov, Andrey [VerfasserIn] |
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| | Capper, David [VerfasserIn] |
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| | Witt, Hendrik [VerfasserIn] |
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| | Tilburg, Cornelis M. van [VerfasserIn] |
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| | Witt, Ruth [VerfasserIn] |
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| | Sahm, Felix [VerfasserIn] |
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| | Reuss, David [VerfasserIn] |
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| | Kölsche, Christian [VerfasserIn] |
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| | Deimling, Andreas von [VerfasserIn] |
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| | Kulozik, Andreas [VerfasserIn] |
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| | Pfister, Stefan [VerfasserIn] |
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| | Witt, Olaf [VerfasserIn] |
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| | Milde, Till [VerfasserIn] |
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| Titel: | Pediatric targeted therapy |
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| Titelzusatz: | clinical feasibility of personalized diagnostics in children with relapsed and progressive tumors |
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| Verf.angabe: | Florian Selt, Alica Deiß, Andrey Korshunov, David Capper, Hendrik Witt, Cornelis M. van Tilburg, David T. W. Jones, Ruth Witt, Felix Sahm, David Reuss, Christian Kölsche, Jonas Ecker, Ina Oehme, Thomas Hielscher, Andreas von Deimling, Andreas E. Kulozik, Stefan M. Pfister, Olaf Witt, Till Milde |
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| E-Jahr: | 2016 |
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| Jahr: | 7 October 2015 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 26.01.2018 |
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| Titel Quelle: | Enthalten in: Brain pathology |
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| Ort Quelle: | Oxford : Wiley-Blackwell, 1990 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 26(2016), 4, Seite 506-516 |
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| ISSN Quelle: | 1750-3639 |
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| Abstract: | The “pediatric targeted therapy” (PTT) program aims to identify the presence and activity of druggable targets and evaluate the clinical benefit of a personalized treatment approach in relapsed or progressive tumors on an individual basis. 10 markers (HDAC2, HR23B, p-AKT, p-ERK, p-S6, p-EGFR, PDGFR-alpha/beta, p53 and BRAFV600E) were analyzed by immunohistochemistry. Pediatric patients with tumors independent of the histological diagnosis, with relapse or progression after treatment according to standard protocols were included. N = 61/145 (42%) cases were eligible for analysis between 2009 and 2013, the most common entities being brain tumors. Immunohistochemical stainings were evaluated by the H-Score (0-300). In 93% of the cases potentially actionable targets were identified. The expressed or activated pathways were histone deacetylase (HDACs; 83.0% of cases positive), EGFR (87.2%), PDGFR (75.9%), p53 (50.0%), MAPK/ERK (43.3%) and PI3K/mTOR (36.1%). Follow-up revealed partial or full implementation of PTT results in treatment decision-making in 41% of the cases. Prolonged disease stabilization responses in single cases were noticed, however, response rates did not differ from cases treated with other modalities. Further studies evaluating the feasibility and clinical benefit of personalized diagnostic approaches using paraffin material are warranted. |
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| DOI: | doi:10.1111/bpa.12326 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: http://dx.doi.org/10.1111/bpa.12326 |
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| | Volltext: http://onlinelibrary.wiley.com/doi/10.1111/bpa.12326/abstract |
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| | DOI: https://doi.org/10.1111/bpa.12326 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | brain tumors |
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| | pediatric oncology |
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| | personalized medicine |
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| | predictive markers |
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| | relapsed childhood tumors |
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| | targeted therapy |
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| K10plus-PPN: | 1567743943 |
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| Verknüpfungen: | → Zeitschrift |
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Pediatric targeted therapy / Selt, Florian [VerfasserIn]; 7 October 2015 (Online-Ressource)
