Status: Bibliographieeintrag
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| Verfasst von: | Reuter, Björn [VerfasserIn]  |
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| | Grudzenski-Theis, Saskia [VerfasserIn] |
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| | Meairs, Stephen [VerfasserIn] |
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| | Bugert, Peter [VerfasserIn] |
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| | Hennerici, Michael G. [VerfasserIn] |
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| | Fatar, Marc [VerfasserIn] |
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| Titel: | Effect of simvastatin on MMPs and TIMPs in human brain endothelial cells and experimental stroke |
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| Verf.angabe: | Björn Reuter, Claus Rodemer, Saskia Grudzenski, Stephen Meairs, Peter Bugert, Michael G. Hennerici, Marc Fatar |
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| E-Jahr: | 2015 |
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| Jahr: | 5 December 2014 |
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| Jahr des Originals: | 2014 |
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| Umfang: | 4 S. |
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| Fussnoten: | Gesehen am 01.02.2018 |
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| Titel Quelle: | Enthalten in: Translational stroke research |
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| Ort Quelle: | Berlin : Springer, 2010 |
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| Jahr Quelle: | 2015 |
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| Band/Heft Quelle: | 6(2015), 2, Seite 156-159 |
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| ISSN Quelle: | 1868-601X |
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| Abstract: | Clinical studies demonstrated favorable effects of statins in stroke beyond lipid-lowering effects. In acute stroke, the disruption of the blood-brain barrier (BBB) is mediated by matrix metalloproteinases (MMPs). A modified MMP metabolism may account for the beneficial effects of statins. Cultured human brain microvascular endothelial cells (BMECs) were pretreated with simvastatin and subjected to oxygen glucose deprivation (OGD). Gene expression and protein secretion of MMP-2 and MMP-9 and the tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 were measured by quantitative real-time polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA). Simvastatin significantly dampened the expression but not secretion of MMP-2 under OGD. MMP-9 synthesis rate was low and unaffected by simvastatin treatment, while the gene expression and protein secretion of TIMP-1 and TIMP-2 were both strongly induced. Our results provide evidence for a positive effect of simvastatin on the MMP metabolism in human BMECs and experimental stroke mainly by means of the increased expression and secretion of TIMP-1 and TIMP-2. |
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| DOI: | doi:10.1007/s12975-014-0381-7 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1007/s12975-014-0381-7 |
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| | Volltext: https://link-springer-com.ezproxy.medma.uni-heidelberg.de/article/10.1007/s12975-014-0381-7 |
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| | DOI: https://doi.org/10.1007/s12975-014-0381-7 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1567987761 |
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| Verknüpfungen: | → Zeitschrift |
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Effect of simvastatin on MMPs and TIMPs in human brain endothelial cells and experimental stroke / Reuter, Björn [VerfasserIn]; 5 December 2014 (Online-Ressource)
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