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Verfasst von:Jaros, Julian A. [VerfasserIn]   i
 Rahmoune, Hassan [VerfasserIn]   i
 Wesseling, Hendrik [VerfasserIn]   i
 Leweke, F. Markus [VerfasserIn]   i
 Ozcan, Sureyya [VerfasserIn]   i
 Guest, Paul C. [VerfasserIn]   i
 Bahn, Sabine [VerfasserIn]   i
Titel:Effects of olanzapine on serum protein phosphorylation patterns in patients with schizophrenia
Verf.angabe:Julian A. Jaros, Hassan Rahmoune, Hendrik Wesseling, F. Markus Leweke, Sureyya Ozcan, Paul C. Guest and Sabine Bahn
E-Jahr:2015
Jahr:15 May 2015
Umfang:10 S.
Fussnoten:Gesehen am 01.02.2018
Titel Quelle:Enthalten in: Proteomics. Clinical applications
Ort Quelle:Weinheim : Wiley VCH, 2007
Jahr Quelle:2015
Band/Heft Quelle:9(2015), 9/10, Seite 907-916
ISSN Quelle:1862-8354
Abstract:Purpose: Previous studies have shown that blood serum phosphoproteins are altered in schizophrenia patients in comparison to controls. However, it is not known whether phosphoproteins are also changed in response to treatment with antipsychotics. Experimental design: Blood samples were taken from patients (n = 23) at baseline and after 6 weeks of olanzapine treatment. Immobilized metal ion affinity chromatography (IMAC) was used for enrichment of serum phosphoproteins and these were analyzed by label-free LC-MS in expression mode (LC-MSE). Results: We identified 11 proteins that were changed significantly in overall abundance and 45 proteins that showed changes in phosphorylation after the antipsychotic treatment. The altered phosphoproteins were mainly involved in the acute phase response, lipid and glucose homeostasis (LXR), retinoic acid signaling (RXR), and complement pathways. Some of the proteins showed a marked increase in phosphorylation, including apolipoprotein A-I (3.4-fold), alpha-1-anti-chymotrypsin (3.1-fold), and apolipoprotein B-100 (2.2-fold). In addition, several proteins showed either decreased phosphorylation (e.g. complement C4A, collagen alpha-1 chain, complement factor H) or a mixture of increased and decreased phoshphorylation (e.g. afamin, complement C5, complement factor B). Finally, 24 of the altered phosphoproteins showed opposite directional changes in a comparison of baseline schizophrenia patients before and after treatment with olanzapine. These included alpha-1B-glycoprotein, apolipoprotein A-IV, vitamin D-binding protein, and prothrombin. Conclusions and clinical relevance: These data demonstrate the potential for future studies of serum phosphoproteins as a readout of physiological function and might have utility in studies aimed at identification of biomarkers for drug response prediction or monitoring.
DOI:doi:10.1002/prca.201400148
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1002/prca.201400148
 Volltext: http://onlinelibrary.wiley.com.ezproxy.medma.uni-heidelberg.de/doi/10.1002/prca.201400148/abstract
 DOI: https://doi.org/10.1002/prca.201400148
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Biomarker
 Drug response
 Monitoring
 Proteomics
 Serum
K10plus-PPN:1567995861
Verknüpfungen:→ Zeitschrift

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