Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Chakrabarti, Alokta [VerfasserIn]  |
| Witt, Olaf [VerfasserIn]  |
Titel: | Targeting histone deacetylase 8 as a therapeutic approach to cancer and neurodegenerative diseases |
Verf.angabe: | Alokta Chakrabarti, Jelena Melesina, Fiona R Kolbinger, Ina Oehme, Johanna Senger, Olaf Witt, Wolfgang Sippl and Manfred Jung |
Umfang: | 26 S. |
Fussnoten: | Gesehen am 06.02.2018 |
Titel Quelle: | Enthalten in: Future medicinal chemistry |
Jahr Quelle: | 2016 |
Band/Heft Quelle: | 8(2016), 13, S. 1609-1634 |
ISSN Quelle: | 1756-8927 |
Abstract: | Histone deacetylase 8 (HDAC8), a unique class I zinc-dependent HDAC, is an emerging target in cancer and other diseases. Its substrate repertoire extends beyond histones to many nonhistone proteins. Besides being a deacetylase, HDAC8 also mediates signaling via scaffolding functions. Aberrant expression or deregulated interactions with transcription factors are critical in HDAC8-dependent cancers. Many potent HDAC8-selective inhibitors with cellular activity and anticancer effects have been reported. We present HDAC8 as a druggable target and discuss inhibitors of different chemical scaffolds with cellular effects. Furthermore, we review HDAC8 activators that revert activity of mutant enzymes. Isotype-selective HDAC8 targeting in patients with HDAC8-relevant cancers is challenging, however, is promising to avoid adverse side effects as observed with pan-HDAC inhibitors. |
DOI: | doi:10.4155/fmc-2016-0117 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Verlag: http://dx.doi.org/10.4155/fmc-2016-0117 |
| Verlag: https://www.future-science.com/doi/10.4155/fmc-2016-0117 |
| DOI: https://doi.org/10.4155/fmc-2016-0117 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1568137087 |
Verknüpfungen: | → Zeitschrift |
Targeting histone deacetylase 8 as a therapeutic approach to cancer and neurodegenerative diseases / Chakrabarti, Alokta [VerfasserIn] (Online-Ressource)
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