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Verfasst von:Shen, Ling [VerfasserIn]   i
 Jonas, Jost B. [VerfasserIn]   i
Titel:Scleral and choroidal volume in relation to axial length in infants with retinoblastoma versus adults with malignant melanomas or end-stage glaucoma
Verf.angabe:Ling Shen, Qi Sheng You, Xiaolin Xu, Fei Gao, Zhibao Zhang, Bin Li, Jost B. Jonas
E-Jahr:2016
Jahr:26 April 2016
Umfang:8 S.
Fussnoten:Gesehen am 06.02.2018
Titel Quelle:Enthalten in: Graefe's archive for clinical and experimental ophthalmology
Ort Quelle:Berlin : Springer, 1854
Jahr Quelle:2016
Band/Heft Quelle:254(2016), 9, Seite 1779-1786
ISSN Quelle:1435-702X
Abstract:PurposeTo measure scleral and choroidal volume in eyes of Chinese, and to assess associations with age and axial length.MethodsWe histomorphometrically examined globes from infants and adults which had been enucleated due to retinoblastoma, uveal melanoma, or absolute painful glaucoma. Thickness of sclera and choroid were measured, and volumes were calculated.ResultsThe study included 225 globes (mean axial length: 24.6 ± 4.2 mm; range:17.0-35.7 mm; mean age: 30.4 ± 22.6 years; range: 1-83 years). Mean computed scleral volume was 648 ± 136 mm3. Scleral volume in children aged <5 years significantly increased with longer axial length (P = 0.001; correlation coefficient r: 0.42) and older age (P = 0.003; r: 0.39) in univariate analysis. In multivariate analysis within the group of children aged ≤2 years, larger scleral volume increased with longer axial length (P = 0.04; standardized correlation coefficient beta: 0.32; correlation coefficient B: 21.6; 95 % confidence interval (CI): 0.52, 42.7) and showed a statistically non-significant tendency to increase with older age (P = 0.06;b eta: 0.30; B: 56.9; 95% CI: −1.5,115). In individuals aged ≥ 5 years, scleral volume was not significantly associated with axial length (P = 0.75) or age (P = 0.13). Mean choroidal volume as measured and calculated in 95 individuals (age: 16-81 years) was 44.1 ± 14.1 mm3, and was not significantly associated with age (P = 0.47; r: −0.08) or axial length (P = 0.83; r: −0.02).ConclusionsThis study on children eyes with retinoblastoma and adult eyes with malignant melanomas or end-stage glaucoma suggests that primary eye growth up to an age of 2 years is associated with an increase in scleral volume. After the age of 2 years, scleral volume and choroidal volume remain unchanged, leading to scleral and choroidal thinning with longer axial length, in particular at the posterior pole.
DOI:doi:10.1007/s00417-016-3345-7
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1007/s00417-016-3345-7
 Volltext: https://link.springer.com/article/10.1007/s00417-016-3345-7
 DOI: https://doi.org/10.1007/s00417-016-3345-7
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1568137605
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