| Online-Ressource |
Verfasst von: | Sobeh, Mansour [VerfasserIn]  |
| Mahmoud, Mona Fouad [VerfasserIn]  |
| Abdelfattah, Mohamed A. O. [VerfasserIn]  |
| El-Beshbishy, Hesham A. [VerfasserIn]  |
| El-Shazly, Assem [VerfasserIn]  |
| Wink, Michael [VerfasserIn]  |
Titel: | Albizia harveyi |
Titelzusatz: | phytochemical profiling, antioxidant, antidiabetic and hepatoprotective activities of the bark extract |
Verf.angabe: | Mansour Sobeh, Mona F. Mahmoud, Mohamed A. O. Abdelfattah, Hesham A. El-Beshbishy, Assem M. El-Shazly, Michael Wink |
Jahr: | 2017 |
Umfang: | 15 S. |
Fussnoten: | Gesehen am 14.02.2018 |
Titel Quelle: | Enthalten in: Medicinal chemistry research |
Ort Quelle: | Cambridge, Mass. [u.a.] : Birkhäuser Boston, 1991 |
Jahr Quelle: | 2017 |
Band/Heft Quelle: | 26(2017), 12, Seite 3091-3105 |
ISSN Quelle: | 1554-8120 |
Abstract: | Profiling the polyphenols in the methanol extract from the bark of Albizia harveyi was performed by HPLC-PDA-ESI-MS/MS analysis. The phytochemical analysis identified 39 compounds, the majority of them were flavan-3-ol derivatives and condensed tannins. Total phenolic content, determined by the Folin-Ciocalteu method amounted to 489 mg gallic acid equivalents/g extract. The extract showed promising antioxidant activities with an EC50 of 3.6 µg/mL and 18.32 mM FeSO4 equivalent/mg extract in radical scavenging assay and ferric reducing antioxidant power assays, respectively. The hepatoprotective potential of the extract in rats was determined in vivo in a d-galactosamine-induced liver toxicity model. A dose of 100 mg/kg (body weight) of the bark extract reduced levels of aspartate aminotransferase, gamma-glutamyltransferase and total bilirubin by 35.7, 65.3, and 23.8% (p < 0.05), respectively whereas glutathione was increased by 59.1%. These effects were similar to silymarin which was used as positive control. The extract (100 mg/kg (body weight) mediated a substantial antidiabetic response in streptozotocin-induced diabetic rats manifested by a significant reduction in serum glucose and lipid peroxides and significant increase of serum insulin. Docking of d-(+) catechin and the dimer (epi)catechin-(epi)catechin into the active site of the enzymes human pancreatic α-amylase, maltase-glucoamylase, and aldol reductase revealed that these enzymes may be possible targets via which, the studied Albizia harveyi extract could exert its antidiabetic effect. |
DOI: | doi:10.1007/s00044-017-2005-8 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1007/s00044-017-2005-8 |
| Volltext: https://link.springer.com/article/10.1007/s00044-017-2005-8 |
| DOI: https://doi.org/10.1007/s00044-017-2005-8 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1569838224 |
Verknüpfungen: | → Zeitschrift |