Albizia harveyi

• Verfasst von: Sobeh, Mansour [VerfasserIn]
• Verfasst von: Mahmoud, Mona Fouad [VerfasserIn]
• Verfasst von: Abdelfattah, Mohamed A. O. [VerfasserIn]
• Verfasst von: El-Beshbishy, Hesham A. [VerfasserIn]
• Verfasst von: El-Shazly, Assem [VerfasserIn]
• Verfasst von: Wink, Michael [VerfasserIn]
• Titel: Albizia harveyi
• Titelzusatz: phytochemical profiling, antioxidant, antidiabetic and hepatoprotective activities of the bark extract
• Verf.angabe: Mansour Sobeh, Mona F. Mahmoud, Mohamed A. O. Abdelfattah, Hesham A. El-Beshbishy, Assem M. El-Shazly, Michael Wink
• Jahr: 2017
• Umfang: 15 S.
• Fussnoten: Gesehen am 14.02.2018
• Titel Quelle: Enthalten in: Medicinal chemistry research
• Ort Quelle: Cambridge, Mass. [u.a.] : Birkhäuser Boston, 1991
• Jahr Quelle: 2017
• Band/Heft Quelle: 26(2017), 12, Seite 3091-3105
• ISSN Quelle: 1554-8120
• DOI: doi:10.1007/s00044-017-2005-8
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1569838224

Abstract

Profiling the polyphenols in the methanol extract from the bark of Albizia harveyi was performed by HPLC-PDA-ESI-MS/MS analysis. The phytochemical analysis identified 39 compounds, the majority of them were flavan-3-ol derivatives and condensed tannins. Total phenolic content, determined by the Folin-Ciocalteu method amounted to 489 mg gallic acid equivalents/g extract. The extract showed promising antioxidant activities with an EC50 of 3.6 µg/mL and 18.32 mM FeSO4 equivalent/mg extract in radical scavenging assay and ferric reducing antioxidant power assays, respectively. The hepatoprotective potential of the extract in rats was determined in vivo in a d-galactosamine-induced liver toxicity model. A dose of 100 mg/kg (body weight) of the bark extract reduced levels of aspartate aminotransferase, gamma-glutamyltransferase and total bilirubin by 35.7, 65.3, and 23.8% (p < 0.05), respectively whereas glutathione was increased by 59.1%. These effects were similar to silymarin which was used as positive control. The extract (100 mg/kg (body weight) mediated a substantial antidiabetic response in streptozotocin-induced diabetic rats manifested by a significant reduction in serum glucose and lipid peroxides and significant increase of serum insulin. Docking of d-(+) catechin and the dimer (epi)catechin-(epi)catechin into the active site of the enzymes human pancreatic α-amylase, maltase-glucoamylase, and aldol reductase revealed that these enzymes may be possible targets via which, the studied Albizia harveyi extract could exert its antidiabetic effect.