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Verfasst von:Galinowski, André [VerfasserIn]   i
 Poustka, Luise [VerfasserIn]   i
 Banaschewski, Tobias [VerfasserIn]   i
 Flor, Herta [VerfasserIn]   i
 Mann, Karl [VerfasserIn]   i
 Rietschel, Marcella [VerfasserIn]   i
Titel:Resilience and corpus callosum microstructure in adolescence
Verf.angabe:A. Galinowski, R. Miranda, H. Lemaitre, M.-L. Paillère Martinot, E. Artiges, H. Vulser, R. Goodman, J. Penttilä, M. Struve, A. Barbot, T. Fadai, L. Poustka, P. Conrod, T. Banaschewski, G.J. Barker, A. Bokde, U. Bromberg, C. Büchel, H. Flor, J. Gallinat, H. Garavan, A. Heinz, B. Ittermann, V. Kappel, C. Lawrence, E. Loth, K. Mann, F. Nees, T. Paus, Z. Pausova, J.-B. Poline, M. Rietschel, T.W. Robbins, M. Smolka, G. Schumann, J.-L. Martinot, and the IMAGEN Consortium
E-Jahr:2015
Jahr:30 March 2015
Umfang:10 S.
Fussnoten:Gesehen am 15.02.2018
Titel Quelle:Enthalten in: Psychological medicine
Ort Quelle:Cambridge : Cambridge University Press, 1970
Jahr Quelle:2015
Band/Heft Quelle:45(2015), 11, Seite 2285-2294
ISSN Quelle:1469-8978
Abstract:Background: Resilience is the capacity of individuals to resist mental disorders despite exposure to stress. Little is known about its neural underpinnings. The putative variation of white-matter microstructure with resilience in adolescence, a critical period for brain maturation and onset of high-prevalence mental disorders, has not been assessed by diffusion tensor imaging (DTI). Lower fractional anisotropy (FA) though, has been reported in the corpus callosum (CC), the brain's largest white-matter structure, in psychiatric and stress-related conditions. We hypothesized that higher FA in the CC would characterize stress-resilient adolescents. Method: Three groups of adolescents recruited from the community were compared: resilient with low risk of mental disorder despite high exposure to lifetime stress (n = 55), at-risk of mental disorder exposed to the same level of stress (n = 68), and controls (n = 123). Personality was assessed by the NEO-Five Factor Inventory (NEO-FFI). Voxelwise statistics of DTI values in CC were obtained using tract-based spatial statistics. Regional projections were identified by probabilistic tractography. Results: Higher FA values were detected in the anterior CC of resilient compared to both non-resilient and control adolescents. FA values varied according to resilience capacity. Seed regional changes in anterior CC projected onto anterior cingulate and frontal cortex. Neuroticism and three other NEO-FFI factor scores differentiated non-resilient participants from the other two groups. Conclusion: High FA was detected in resilient adolescents in an anterior CC region projecting to frontal areas subserving cognitive resources. Psychiatric risk was associated with personality characteristics. Resilience in adolescence may be related to white-matter microstructure.
DOI:doi:10.1017/S0033291715000239
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1017/S0033291715000239
 Volltext: https://www-cambridge-org.ezproxy.medma.uni-heidelberg.de/core/journals/psychological-medicine/article/resilience-and-co ...
 DOI: https://doi.org/10.1017/S0033291715000239
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adolescence
 corpus callosum
 DAWBA
 DTI
 NEO-FFI
 resilience
 tractography
K10plus-PPN:1569892679
Verknüpfungen:→ Zeitschrift

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