Hypothalamic-pituitary-adrenal axis, childhood adversity and adolescent nonsuicidal self-injury

• Verfasst von: Reichl, Corinna [VerfasserIn]
• Verfasst von: Heyer, Anne [VerfasserIn]
• Verfasst von: Brunner, Romuald [VerfasserIn]
• Verfasst von: Parzer, Peter [VerfasserIn]
• Verfasst von: Völker, Julia Madeleine [VerfasserIn]
• Verfasst von: Resch, Franz [VerfasserIn]
• Verfasst von: Kaess, Michael [VerfasserIn]
• Titel: Hypothalamic-pituitary-adrenal axis, childhood adversity and adolescent nonsuicidal self-injury
• Verf.angabe: Corinna Reichl, Anne Heyer, Romuald Brunner, Peter Parzer, Julia Madeleine Völker, Franz Resch, Michael Kaess
• E-Jahr: 2016
• Jahr: 15 September 2016
• Umfang: 9 S.
• Fussnoten: Gesehen am 15.02.2018
• Titel Quelle: Enthalten in: Psychoneuroendocrinology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1975
• Jahr Quelle: 2016
• Band/Heft Quelle: 74(2016), Seite 203-211
• ISSN Quelle: 1873-3360
• DOI: doi:10.1016/j.psyneuen.2016.09.011
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Adolescence
• Sach-SW: Childhood adversity
• Sach-SW: Cortisol awakening response
• Sach-SW: Hair cortisol
• Sach-SW: Hypothalamus-pituitary-adrenal-axis
• Sach-SW: Non-suicidal self-injury
• K10plus-PPN: 1569894981

Abstract

Background: whereas childhood adversity (CA) and the hypothalamus-pituitary-adrenal (HPA) axis have been suggested to play a major role in the etiology of non-suicidal self-injury (NSSI), no study has thus far investigated both its associations and interactions with adolescent NSSI. Method: We investigated CA (antipathy, neglect, physical, psychological, and sexual abuse) and indices of HPA axis activity (salivary and hair cortisol) in a clinical sample of 26 adolescents engaging in NSSI and 26 age- and gender-matched healthy controls (HC). We used standardized interviews for the assessment of CA (CECA), NSSI (SITBI-G), and axis I diagnoses (MINI-KID). Salivary cortisol sampling was surveyed using a monitoring system and instructed via telephone calls. Results: Adolescents engaging in NSSI exhibited significantly higher cortisol awakening responses compared to HC. No differences were found with respect to the diurnal slope or hair cortisol. In the presence of CA, healthy adolescents showed flatted diurnal cortisol slopes while those engaging in NSSI exhibited significantly steeper ones. Conclusions: Our findings indicate that adolescents engaging in NSSI may exhibit a stronger cortisol awakening response, potentially in expectation of strain. However, elevated cortisol levels may not be maintained throughout the day, especially among adolescents with a history of CA.