Strategien zur nichtinvasiven Diagnostik des Melanoms

• Verfasst von: Müller-Christmann, Christine [VerfasserIn]
• Verfasst von: Hänßle, Holger [VerfasserIn]
• Titel: Strategien zur nichtinvasiven Diagnostik des Melanoms
• Paralleltitel: Strategies for the noninvasive diagnosis of melanoma
• Verf.angabe: C. Fink, H.A. Haenssle
• E-Jahr: 2016
• Jahr: 19. Mai 2016
• Umfang: 10 S.
• Fussnoten: Gesehen am 16.02.2018
• Titel Quelle: Enthalten in: Der Hautarzt
• Ort Quelle: Berlin : Springer, 1994
• Jahr Quelle: 2016
• Band/Heft Quelle: 67(2016), 7, Seite 519-528
• ISSN Quelle: 1432-1173
• DOI: doi:10.1007/s00105-016-3796-0
• Datenträger: Online-Ressource
• Sprache: ger eng
• K10plus-PPN: 1569939128

Abstract

The diagnosis of advanced cutaneous melanoma may easily be made by the unaided eye, followed by excisional biopsy and histopathological examination. However, in the setting of melanoma screening examinations in high-risk patients with many nevi, dermatologists are challenged with the differentiation of atypical but benign nevi and early invasive or in situ melanomas. In this situation, there is a real need for additional, noninvasive examination techniques that may serve as an aide to decide for or against an excisional biopsy. Conventional dermoscopy is a well-established examination procedure and an increase in sensitivity was confirmed by two independent meta-analyses. Moreover, dynamic changes or newly developed pigmented lesions may be detected by sequential digital dermoscopy or (automated) total body photography, respectively. Over the past years, a number of medicinal products gained market access after licensing by American and European agencies for the noninvasive diagnosis of cutaneous neoplasms. These devices are based on technologies including in vivo reflectance confocal microscopy, multispectral analysis, electrical impedance spectroscopy, or Raman spectroscopy. Other technologies are still on the verge of becoming less experimental but more clinically applicable for diagnosing melanoma (in vivo multiphoton tomography, stepwise two-photon laser spectroscopy, infrared thermal image analysis, epidermal genetic information retrieval). This review provides a concise overview of general principles and sheds light on indication and added value for dermatologists.