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Verfasst von:Muckenhuber, Alexander [VerfasserIn]   i
 Jesinghaus, Moritz [VerfasserIn]   i
 Bergmann, Frank [VerfasserIn]   i
 Stenzinger, Albrecht [VerfasserIn]   i
 Weichert, Wilko [VerfasserIn]   i
Titel:Profiling of cMET and HER family receptor expression in pancreatic ductal adenocarcinomas and corresponding lymph node metastasis to assess relevant pathways for targeted therapies
Titelzusatz:looking at the soil before planting the seed
Verf.angabe:Alexander Muckenhuber, Galina Babitzki, Marlene Thomas, Gabriele Hölzlwimmer, Magdalena Zajac, Moritz Jesinghaus, Frank Bergmann, Jens Werner, Albrecht Stenzinger, and Wilko Weichert
E-Jahr:2016
Jahr:September 2016
Umfang:8 S.
Fussnoten:Gesehen am 16.02.2018
Titel Quelle:Enthalten in: Pancreas
Ort Quelle:Philadelphia, Pa. : Lippincott Williams & Wilkins, 1986
Jahr Quelle:2016
Band/Heft Quelle:45(2016), 8, Seite 1167-1174
ISSN Quelle:1536-4828
Abstract:Objectives Comprehensive assessment of cMET and HER family receptor tyrosine kinases expression, changes of expression during metastatic progression, amplification status of the MET gene, and correlations with patient characteristics in pancreatic ductal adenocarcinoma (PDAC) was conducted. Methods We investigated 56 PDACs and corresponding lymph node metastases for HER1 to HER4 and cMET expression by immunohistochemistry, as well as cMET gene copy numbers by chromogenic in situ hybridization. Results Of all receptor tyrosine kinases evaluated, cMET expression was highest with 46.5% of tumors showing moderate or strong expression and a weak correlation with gene copy number status (P = 0.04; Spearman ρ = 0.28). cMET expression was increased in metastases. In contrast, expression levels of HER family receptors were generally low both in primaries and metastases. A weak yet significant correlation of HER1 and cMET expression levels was observed (P < 0.001; Spearman ρ = 0.44) and HER1 was often present in poorly differentiated tumors (G3, P = 0.049). Conclusions Our data suggest that cMET might constitute an interesting molecule for combining targeted and chemotherapeutic approaches in PDAC, because expression is frequent and increased during metastatic progression. In PDAC, cMET protein expression might be a more useful stratification biomarker than cMET gene amplification, which does not seem to be its primary regulator.
DOI:doi:10.1097/MPA.0000000000000604
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1097/MPA.0000000000000604
 Volltext: https://journals.lww.com/pancreasjournal/Abstract/2016/09000/Profiling_of_cMET_and_HER_Family_Receptor.14.aspx
 DOI: https://doi.org/10.1097/MPA.0000000000000604
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1569939500
Verknüpfungen:→ Zeitschrift

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