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Verfasst von:Ghisleni, Carmen [VerfasserIn]   i
 Brandeis, Daniel [VerfasserIn]   i
Titel:Effects of steroid hormones on sex differences in cerebral perfusion
Verf.angabe:Carmen Ghisleni, Steffen Bollmann, Anna Biason-Lauber, Simon-Shlomo Poil, Daniel Brandeis, Ernst Martin, Lars Michels, Martin Hersberger, John Suckling, Peter Klaver, Ruth L. O'Gorman
E-Jahr:2015
Jahr:September 10, 2015
Umfang:15 S.
Fussnoten:Gesehen am 28.02.2018
Titel Quelle:Enthalten in: PLOS ONE
Ort Quelle:San Francisco, California, US : PLOS, 2006
Jahr Quelle:2015
Band/Heft Quelle:10(2015,9) Artikel-Nummer e0135827, 15 Seiten
ISSN Quelle:1932-6203
Abstract:Sex differences in the brain appear to play an important role in the prevalence and progression of various neuropsychiatric disorders, but to date little is known about the cerebral mechanisms underlying these differences. One widely reported finding is that women demonstrate higher cerebral perfusion than men, but the underlying cause of this difference in perfusion is not known. This study investigated the putative role of steroid hormones such as oestradiol, testosterone, and dehydroepiandrosterone sulphate (DHEAS) as underlying factors influencing cerebral perfusion. We acquired arterial spin labelling perfusion images of 36 healthy adult subjects (16 men, 20 women). Analyses on average whole brain perfusion levels included a multiple regression analysis to test for the relative impact of each hormone on the global perfusion. Additionally, voxel-based analyses were performed to investigate the sex difference in regional perfusion as well as the correlations between local perfusion and serum oestradiol, testosterone, and DHEAS concentrations. Our results replicated the known sex difference in perfusion, with women showing significantly higher global and regional perfusion. For the global perfusion, DHEAS was the only significant predictor amongst the steroid hormones, showing a strong negative correlation with cerebral perfusion. The voxel-based analyses revealed modest sex-dependent correlations between local perfusion and testosterone, in addition to a strong modulatory effect of DHEAS in cortical, subcortical, and cerebellar regions. We conclude that DHEAS in particular may play an important role as an underlying factor driving the difference in cerebral perfusion between men and women.
DOI:doi:10.1371/journal.pone.0135827
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: http://dx.doi.org/10.1371/journal.pone.0135827
 kostenfrei: Volltext: http://journals.plos.org.ezproxy.medma.uni-heidelberg.de/plosone/article?id=10.1371/journal.pone.0135827
 DOI: https://doi.org/10.1371/journal.pone.0135827
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Neuroimaging
 Blood flow
 Magnetic resonance imaging
 Perfusion
 Sex hormones
 Steroid hormones
 Steroids
 Testosterone
K10plus-PPN:1570267618
Verknüpfungen:→ Zeitschrift

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