Status: Bibliographieeintrag
Standort: ---
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| Online-Ressource |
Verfasst von: | Rabionet Roig, Mariona [VerfasserIn]  |
| Porubský, Štefan [VerfasserIn]  |
Titel: | Male meiotic cytokinesis requires ceramide synthase 3-dependent sphingolipids with unique membrane anchors |
Verf.angabe: | Mariona Rabionet, Aline Bayerle, Richard Jennemann, Hans Heid, Jens Fuchser, Christian Marsching, Stefan Porubsky, Christian Bolenz, Florian Guillou, Hermann-Josef Gröne, Karin Gorgas and Roger Sandhoff |
E-Jahr: | 2015 |
Jahr: | 04 June 2015 |
Umfang: | 17 S. |
Fussnoten: | Gesehen am 07.03.2018 |
Titel Quelle: | Enthalten in: Human molecular genetics |
Ort Quelle: | Oxford : Oxford Univ. Press, 1992 |
Jahr Quelle: | 2015 |
Band/Heft Quelle: | 24(2015), 17, Seite 4792-4808 |
ISSN Quelle: | 1460-2083 |
Abstract: | Somatic cell cytokinesis was shown to involve the insertion of sphingolipids (SLs) to midbodies prior to abscission. Spermatogenic midbodies transform into stable intercellular bridges (ICBs) connecting clonal daughter cells in a syncytium. This process requires specialized SL structures. (1) Using high resolution-mass spectrometric imaging, we show in situ a biphasic pattern of SL synthesis with testis-specific anchors. This pattern correlates with and depends on ceramide synthase 3 (CerS3) localization in both, pachytene spermatocytes until completion of meiosis and elongating spermatids. (2) Blocking the pathways to germ cell-specific ceramides (CerS3-KO) and further to glycosphingolipids (glucosylceramide synthase-KO) in mice highlights the need for special SLs for spermatid ICB stability. In contrast to somatic mitosis these SLs require ultra-long polyunsaturated anchors with unique physico-chemical properties, which can only be provided by CerS3. Loss of these anchors causes enhanced apoptosis during meiosis, formation of multinuclear giant cells and spermatogenic arrest. Hence, testis-specific SLs, which we also link to CerS3 in human testis, are quintessential for male fertility. |
DOI: | doi:10.1093/hmg/ddv204 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
teilw. kostenfrei: Volltext: http://dx.doi.org/10.1093/hmg/ddv204 |
| teilw. kostenfrei: Volltext: https://academic-oup-com.ezproxy.medma.uni-heidelberg.de/hmg/article/24/17/4792/647747 |
| DOI: https://doi.org/10.1093/hmg/ddv204 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1570614474 |
Verknüpfungen: | → Zeitschrift |
Male meiotic cytokinesis requires ceramide synthase 3-dependent sphingolipids with unique membrane anchors / Rabionet Roig, Mariona [VerfasserIn]; 04 June 2015 (Online-Ressource)
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