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Status: Bibliographieeintrag

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Verfasst von:Zhan, Tianzuo [VerfasserIn]   i
 Hahn, Felix [VerfasserIn]   i
 Betge, Johannes [VerfasserIn]   i
 Kähler, Georg [VerfasserIn]   i
 Ebert, Matthias [VerfasserIn]   i
 Belle, Sebastian [VerfasserIn]   i
Titel:Frequent co-occurrence of high-grade dysplasia in large flat colonic polyps (>20 mm) and synchronous polyps
Verf.angabe:Tianzuo Zhan, Felix Hahn, Thomas Hielscher, Johannes Betge, Georg Kähler, Matthias P. Ebert and Sebastian Belle
E-Jahr:2015
Jahr:10 July 2015
Umfang:8$p15(2015) Artikel-Nummer 82, 8 Seiten
Fussnoten:Gesehen am 15.03.2018
Titel Quelle:Enthalten in: BMC gastroenterology
Ort Quelle:London : BioMed Central, 2001
Jahr Quelle:2015
Band/Heft Quelle:15(2015)
ISSN Quelle:1471-230X
Abstract:Background: Large colonic polyps are associated with advanced dysplasia, but prevalence and characteristics of synchronous polyps in patients with large flat colonic polyps are poorly investigated. This study aims to characterize clinicopathological features of large flat colonic polyps and their impact on occurrence and characteristics of synchronous polyps. Methods: A total of 802 patients that underwent endoscopic mucosal resection (EMR) of flat colonic polyps >20 mm from 2003 to 2014 in an academic endoscopy unit were retrospectively analyzed for size, location and histology of large polyps and synchronous polyps. Results: Average size of large polyps was 34.1 mm (range 20-150 mm, standard deviation 16.1 mm). Histology included 52.5 % adenomas with low-grade dysplasia (LGD), 26.7 % with high-grade dysplasia (HGD), 9.6 % serrated polyps and 11.2 % adenocarcinomas. The majority of large polyps were localized in the proximal colon (61 %). 72.2 % of adenocarcinomas were found in the distal colon, while 80.5 % of all serrated polyps were detected in the proximal colon. Increase in polyp size, advanced age and location in the distal colon were associated with presence of HGD/adenocarcinoma in large polyps, as identified by multivariate analysis. Synchronous polyps were detected in 67.2 % of patients undergoing complete colonoscopy during EMR. Presence of HGD/adenocarcinoma in the large polyp, localization of any synchronous polyp in the rectosigmoid colon and occurrence of multiple synchronous polyps were associated with presence of HGD/adenocarcinoma in synchronous polyps. Conclusions: Synchronous polyps are frequently found in patients with large flat colonic polyps. The prevalence of synchronous polyps with high grade dysplasia is highest in patients with large flat polyps containing HGD/adenocarcinoma.
DOI:doi:10.1186/s12876-015-0312-4
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1186/s12876-015-0312-4
 Volltext: https://doi.org/10.1186/s12876-015-0312-4
 DOI: https://doi.org/10.1186/s12876-015-0312-4
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adenoma
 Colonic polyp
 Colonoscopy
 Endoscopic mucosal resection
 Synchronous polyps
K10plus-PPN:1571096043
Verknüpfungen:→ Zeitschrift

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