Status: Bibliographieeintrag
Standort: ---
Exemplare:
---
| Online-Ressource |
Verfasst von: | Keil, Melanie [VerfasserIn]  |
| Lanz, Tobias [VerfasserIn]  |
| Wick, Wolfgang [VerfasserIn]  |
| Platten, Michael [VerfasserIn]  |
Titel: | General control non-derepressible 2 (GCN2) in T cells controls disease progression of autoimmune neuroinflammation |
Verf.angabe: | Melanie Keil, Jana K. Sonner, Tobias V. Lanz, Iris Oezen, Theresa Bunse, Stefan Bittner, Hannah V. Meyer, Sven G. Meuth, Wolfgang Wick, Michael Platten |
Umfang: | 10 S. |
Fussnoten: | Gesehen am 21.03.2018 |
Titel Quelle: | Enthalten in: Journal of neuroimmunology |
Jahr Quelle: | 2016 |
Band/Heft Quelle: | 297(2016), S. 117-126 |
ISSN Quelle: | 1872-8421 |
Abstract: | Relapsing-remitting multiple sclerosis (MS)22MS: multiple sclerosis. is characterized by phases of acute neuroinflammation followed by spontaneous remission. Termination of inflammation is accompanied by an influx of regulatory T cells (Tregs).33Tregs: regulatory T cells. The molecular mechanisms responsible for directing Tregs into the inflamed CNS tissue, however, are incompletely understood. In an MS mouse model we show that the stress kinase general control non-derepressible 2 (GCN2),44GCN2: general control non-derepressible 2. expressed in T cells, contributes to the resolution of autoimmune neuroinflammation. Failure to recover from acute inflammation was associated with reduced frequencies of CNS-infiltrating Tregs. GCN2 deficient Tregs displayed impaired migration to a CCL2 gradient. These data suggest an important contribution of the T cell stress response to the resolution of autoimmune neuroinflammation. |
DOI: | doi:10.1016/j.jneuroim.2016.05.014 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Verlag: http://dx.doi.org/10.1016/j.jneuroim.2016.05.014 |
| Verlag: http://www.sciencedirect.com/science/article/pii/S0165572816301199 |
| DOI: https://doi.org/10.1016/j.jneuroim.2016.05.014 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1571293779 |
Verknüpfungen: | → Zeitschrift |
General control non-derepressible 2 (GCN2) in T cells controls disease progression of autoimmune neuroinflammation / Keil, Melanie [VerfasserIn] (Online-Ressource)
68235026