Carbon ion radiotherapy decreases the impact of tumor heterogeneity on radiation response in experimental prostate tumors

• Verfasst von: Glowa, Christin [VerfasserIn]
• Verfasst von: Karger, Christian [VerfasserIn]
• Verfasst von: Brons, Stephan [VerfasserIn]
• Verfasst von: Huber, Peter E. [VerfasserIn]
• Verfasst von: Debus, Jürgen [VerfasserIn]
• Verfasst von: Peschke, Peter [VerfasserIn]
• Titel: Carbon ion radiotherapy decreases the impact of tumor heterogeneity on radiation response in experimental prostate tumors
• Verf.angabe: Christin Glowa, Christian P. Karger, Stephan Brons, Dawen Zhao, Ralph P. Mason, Peter E. Huber, Jürgen Debus, Peter Peschke
• E-Jahr: 2016
• Jahr: 17 May 2016
• Umfang: 7 S.
• Fussnoten: Gesehen am 21.03.2018
• Titel Quelle: Enthalten in: Cancer letters
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1975
• Jahr Quelle: 2016
• Band/Heft Quelle: 378(2016), 2, Seite 97-103
• ISSN Quelle: 1872-7980
• DOI: doi:10.1016/j.canlet.2016.05.013
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Carbon ion radiotherapy
• Sach-SW: Prostate tumor
• Sach-SW: Relative biological effectiveness (RBE)
• Sach-SW: Tumor heterogeneity
• K10plus-PPN: 1571299157

Abstract

Objective To quantitatively study the impact of intrinsic tumor characteristics and microenvironmental factors on local tumor control after irradiation with carbon (12C-) ions and photons in an experimental prostate tumor model. Material and Methods Three sublines of a syngeneic rat prostate tumor (R3327) differing in grading (highly (-H) moderately (-HI) or anaplastic (-AT1)) were irradiated with increasing single doses of either 12C-ions or 6 MV photons in Copenhagen rats. Primary endpoint was local tumor control within 300 days. The relative biological effectiveness (RBE) of 12C-ions was calculated from the dose at 50% tumor control probability (TCD50) of photons and 12C-ions and was correlated with histological, physiological and genetic tumor parameters. Results Experimental findings demonstrated that (i) TCD50-values between the three tumor sublines differed less for 12C-ions (23.6-32.9 Gy) than for photons (38.2-75.7 Gy), (ii) the slope of the dose-response curve for each tumor line was steeper for 12C-ions than for photons, and (iii) the RBE increased with tumor grading from 1.62 ± 0.11 (H) to 2.08 ± 0.13 (HI) to 2.30 ± 0.08 (AT1). Conclusion The response to 12C-ions is less dependent on resistance factors as well as on heterogeneity between and within tumor sublines as compared to photons. A clear correlation between decreasing differentiation status and increasing RBE was found. 12C-ions may therefore be a therapeutic option especially in patients with undifferentiated prostate tumors, expressing high resistance against photons.