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Verfasst von:Glowa, Christin [VerfasserIn]   i
 Karger, Christian [VerfasserIn]   i
 Brons, Stephan [VerfasserIn]   i
 Huber, Peter E. [VerfasserIn]   i
 Debus, Jürgen [VerfasserIn]   i
 Peschke, Peter [VerfasserIn]   i
Titel:Carbon ion radiotherapy decreases the impact of tumor heterogeneity on radiation response in experimental prostate tumors
Verf.angabe:Christin Glowa, Christian P. Karger, Stephan Brons, Dawen Zhao, Ralph P. Mason, Peter E. Huber, Jürgen Debus, Peter Peschke
E-Jahr:2016
Jahr:17 May 2016
Umfang:7 S.
Fussnoten:Gesehen am 21.03.2018
Titel Quelle:Enthalten in: Cancer letters
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1975
Jahr Quelle:2016
Band/Heft Quelle:378(2016), 2, Seite 97-103
ISSN Quelle:1872-7980
Abstract:Objective To quantitatively study the impact of intrinsic tumor characteristics and microenvironmental factors on local tumor control after irradiation with carbon (12C-) ions and photons in an experimental prostate tumor model. Material and Methods Three sublines of a syngeneic rat prostate tumor (R3327) differing in grading (highly (-H) moderately (-HI) or anaplastic (-AT1)) were irradiated with increasing single doses of either 12C-ions or 6 MV photons in Copenhagen rats. Primary endpoint was local tumor control within 300 days. The relative biological effectiveness (RBE) of 12C-ions was calculated from the dose at 50% tumor control probability (TCD50) of photons and 12C-ions and was correlated with histological, physiological and genetic tumor parameters. Results Experimental findings demonstrated that (i) TCD50-values between the three tumor sublines differed less for 12C-ions (23.6-32.9 Gy) than for photons (38.2-75.7 Gy), (ii) the slope of the dose-response curve for each tumor line was steeper for 12C-ions than for photons, and (iii) the RBE increased with tumor grading from 1.62 ± 0.11 (H) to 2.08 ± 0.13 (HI) to 2.30 ± 0.08 (AT1). Conclusion The response to 12C-ions is less dependent on resistance factors as well as on heterogeneity between and within tumor sublines as compared to photons. A clear correlation between decreasing differentiation status and increasing RBE was found. 12C-ions may therefore be a therapeutic option especially in patients with undifferentiated prostate tumors, expressing high resistance against photons.
DOI:doi:10.1016/j.canlet.2016.05.013
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: http://dx.doi.org/10.1016/j.canlet.2016.05.013
 Volltext: http://www.sciencedirect.com/science/article/pii/S0304383516303184
 DOI: https://doi.org/10.1016/j.canlet.2016.05.013
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Carbon ion radiotherapy
 Prostate tumor
 Relative biological effectiveness (RBE)
 Tumor heterogeneity
K10plus-PPN:1571299157
Verknüpfungen:→ Zeitschrift

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