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Verfasst von:Schick, Anita [VerfasserIn]   i
 Adam, Ruth [VerfasserIn]   i
 Vollmayr, Barbara [VerfasserIn]   i
 Kühner, Christine [VerfasserIn]   i
Titel:Neural correlates of valence generalization in an affective conditioning paradigm
Verf.angabe:Anita Schick, Ruth Adam, Barbara Vollmayr, Christine Kuehner, Philipp Kanske, Michèle Wessa
E-Jahr:2015
Jahr:1 October 2015
Umfang:10 S.
Fussnoten:Gesehen am 21.03.2018
Titel Quelle:Enthalten in: Behavioural brain research
Ort Quelle:Amsterdam : Elsevier, 1980
Jahr Quelle:2015
Band/Heft Quelle:292(2015), Seite 147-156
ISSN Quelle:1872-7549
Abstract:In case of uncertainty, predictions that are based on prior, similar experiences guide our decision by processes of generalization. Over-generalization of negative information has been identified as an important feature of several psychopathologies, including anxiety disorders and depression, and might underlie biased interpretation of ambiguous information. Here, we investigated the neural correlates of valence generalization to ambiguous stimuli using a translational affective conditioning task during fMRI. Twenty-five healthy individuals participated in a conditioning procedure with (1) an initial acquisition phase, where participants learned the positive and negative valence of two different tones (reference tones) through their responses and subsequent feedback and (2) a test phase, where participants were presented with the previously learned reference tones and three additional tones with intermediate frequency to the learned reference tones. By recording the responses to these intermediate stimuli we were able to assess the participantś interpretation of ambiguous tones as either positive or negative. Behavioral results revealed a graded response pattern to the three intermediate tones, which was mirrored on the neural level. More specifically, parametric analyses OF BOLD responses to all five tones revealed a linear effect in bilateral anterior insula and SMA with lowest activation to the negative reference tone and highest activation to the positive negative tone. In addition, a cluster in the SMA showed a reverse-quadratic response, i.e., the strongest response for the most ambiguous tone. These findings suggest overlapping regions in the salience network that mediate valence generalization and decision-making under ambiguity, potentially underlying biased ambiguous cue interpretation.
DOI:doi:10.1016/j.bbr.2015.06.009
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.bbr.2015.06.009
 Volltext: http://www.sciencedirect.com/science/article/pii/S016643281530036X
 DOI: https://doi.org/10.1016/j.bbr.2015.06.009
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Auditory discrimination
 Cognitive bias
 fMRI
 Salience
 Uncertainty
K10plus-PPN:157130777X
Verknüpfungen:→ Zeitschrift

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