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Verfasst von:Oelke, Matthias [VerfasserIn]   i
 Wehling, Martin [VerfasserIn]   i
Titel:Appropriateness of oral drugs for long-term treatment of lower urinary tract symptoms in older persons
Titelzusatz:results of a systematic literature review and international consensus validation process (LUTS-FORTA 2014)
Verf.angabe:Matthias Oelke, Klaus Becher, David Castro-Diaz, Emmanuel Chartier-Kastler, Mike Kirby, Adrian Wagg, Martin Wehling
E-Jahr:2015
Jahr:1 September 2015
Umfang:11 S.
Fussnoten:Gesehen am 22.03.2018
Titel Quelle:Enthalten in: Age & ageing
Ort Quelle:Oxford : Oxford Univ. Press, 1972
Jahr Quelle:2015
Band/Heft Quelle:44(2015), 5, Seite 745-755
ISSN Quelle:1468-2834
Abstract:Aim: we aimed to systematically review drugs to treat lower urinary tract symptoms (LUTS) regularly used in older persons to classify appropriate and inappropriate drugs based on efficacy, safety and tolerability by using the Fit fOR The Aged (FORTA) classification. Methods: to evaluate the efficacy, safety and tolerability of drugs used for treatment of LUTS in older persons, a systematic review was performed. Papers on clinical trials and summaries of individual product characteristics were analysed regarding efficacy and safety in older persons (≥65 years). The most frequently used drugs were selected based on current prescription data. An interdisciplinary international expert panel assessed the drugs in a Delphi process. Results: for the 16 drugs included here, a total of 896 citations were identified; of those, only 25 reported clinical trials with explicit data on, or solely performed in older people, underlining the lack of evidence in older people for drug treatment of LUTS. No drug was rated at the FORTA-A-level (indispensable). Only three were assigned to FORTA B (beneficial): dutasteride, fesoterodine and finasteride. The majority was rated FORTA C (questionable): darifenacin, mirabegron, extended release oxybutynin, silodosin, solifenacin, tadalafil, tamsulosin, tolterodine and trospium. FORTA D (avoid) was assigned to alfuzosin, doxazosin, immediate release oxybutynin, propiverine and terazosin. Conclusions: dutasteride, fesoterodine and finasteride were classified as beneficial in older persons or frail elderly people (FORTA B). For most drugs, in particular those from the group of α-blockers and antimuscarinics, use in this group seems questionable (FORTA C) or should be avoided (FORTA D).
DOI:doi:10.1093/ageing/afv077
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1093/ageing/afv077
 Volltext: https://academic-oup-com.ezproxy.medma.uni-heidelberg.de/ageing/article/44/5/745/52038
 DOI: https://doi.org/10.1093/ageing/afv077
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1571320326
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