| |  Online-Ressource |
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| Verfasst von: | Biswas, Siladitta [VerfasserIn]  |
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| | Adrian, Monica [VerfasserIn] |
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| | Schledzewski, Kai [VerfasserIn] |
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| | Weber, Jochen [VerfasserIn] |
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| | Winkler, Manuel [VerfasserIn] |
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| | Goerdt, Sergij [VerfasserIn] |
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| | Géraud, Cyrill [VerfasserIn] |
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| Titel: | Counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilrα during the LPS-mediated immune response of murine macrophages |
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| Verf.angabe: | Siladitta Biswas, Monica Adrian, Konstantin Evdokimov, Kai Schledzewski, Jochen Weber, Manuel Winkler, Sergij Goerdt, Cyrill Géraud |
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| E-Jahr: | 2015 |
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| Jahr: | 4 September 2015 |
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| Umfang: | 6 S. |
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| Fussnoten: | Gesehen am 22.03.2018 |
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| Titel Quelle: | Enthalten in: Biochemical and biophysical research communications |
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| Ort Quelle: | [Amsterdam] : Elsevier B.V., 1959 |
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| Jahr Quelle: | 2015 |
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| Band/Heft Quelle: | 464(2015), 4, Seite 1078-1083 |
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| ISSN Quelle: | 1090-2104 |
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| Abstract: | Liver endothelial differentiation-associated protein-1 (Leda-1/Pianp) is a type-I-transmembrane protein that is able to bind and activate immune inhibitory receptor Pilrα. Here we show that Leda-1/Pianp is strain-specifically expressed in lymphoid organs and macrophages of Th2-prone BALB/c mice but not of Th1-prone C57BL/6J mice. LPS stimulation of BALB/c bone marrow-derived macrophages (BMM) and macrophage-like Raw 264.7 cells conversely regulated Leda-1/Pianp and Pilrα expression. Pilrα induction was caused by LPS-mediated transcriptional modulation and increased mRNA expression. On the other hand, the LPS-mediated decline of Leda-1/Pianp expression was the result of proteolytic degradation by matrix metalloproteinases. In summary, these findings demonstrate that counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilrα is part of the complex innate immune response of macrophages and its genetically determined strain-specific modulation. |
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| DOI: | doi:10.1016/j.bbrc.2015.07.079 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1016/j.bbrc.2015.07.079 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0006291X15303090 |
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| | DOI: https://doi.org/10.1016/j.bbrc.2015.07.079 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | M1 |
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| | M2 |
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| | Macrophage differentiation |
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| | Macrophage polarity |
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| | Proteolysis |
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| | Shedding |
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| K10plus-PPN: | 1571324100 |
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| Verknüpfungen: | → Zeitschrift |
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Counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilrα during the LPS-mediated immune response of murine macrophages / Biswas, Siladitta [VerfasserIn]; 4 September 2015 (Online-Ressource)
