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Verfasst von:Samhaber, Kinga [VerfasserIn]   i
 Hänßle, Holger [VerfasserIn]   i
Titel:Morphologic criteria of vesiculobullous skin disorders by in vivo reflectance confocal microscopy
Verf.angabe:Samhaber Kinga T., Buhl Timo, Brauns Birka, Hofmann Lars, Mitteldorf Christina, Seitz Cornelia S., Schön Michael P., Rosenberger Albert, Haenssle Holger A.
Umfang:7 S.
Fussnoten:Gesehen am 26.03.2018
Titel Quelle:Enthalten in: Deutsche Dermatologische Gesellschaft: Journal der Deutschen Dermatologischen Gesellschaft
Jahr Quelle:2016
Band/Heft Quelle:14(2016), 8, S. 797-805
ISSN Quelle:1610-0387
Abstract:Summary Background and objectives Reflectance confocal microscopy (RCM) may be a useful method for accurate, rapid, and noninvasive bedside diagnosis of vesiculobullous skin diseases (VSD). The main outcome measure of this study was a descriptive statistical analysis of RCM features associated with selected group of VSD. Patients and methods Single?center, observational study at a university?based dermatology department. Forty skin lesions in 24 patients with bullous pemphigoid (BP), varicella zoster virus infection (VZI), or allergic contact dermatitis (ACD) were assessed. Results Patients with BP, VZI, and ACD were assessed for the presence of a large spectrum of RCM features, among others including histopathological correlates for spongiosis, vesicles/blisters, epidermal necrosis, pleomorphic ballooned keratinocytes, and inflammatory infiltrate. The three conditions showed distinct patterns of occurrence with respect to these RCM features. Using a multivariate regression model, we identified sets of morphologic features in BP (vesicles/blisters at the dermoepidermal junction, inflammatory infiltrate within blisters and basal epidermal layers, spongiosis in basal epidermal layers), VZI (acantholysis in the stratum spinosum, epidermal necrosis, pleomorphic ballooned keratinocytes, multinucleated giant cells), and ACD (microvesicles, spongiosis, and prominent inflammatory infiltrate in the stratum granulosum/spinosum). Conclusions RCM seems to be a useful tool in the evaluation and differentiation of a selected group of VSD, and offers a good correlation with histopathological findings.
DOI:doi:10.1111/ddg.13058
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Verlag: http://dx.doi.org/10.1111/ddg.13058
 Verlag: https://onlinelibrary.wiley.com/doi/abs/10.1111/ddg.13058
 DOI: https://doi.org/10.1111/ddg.13058
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1571447393
Verknüpfungen:→ Zeitschrift

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