Puberty marks major changes in the hippocampal and cortical c-Fos activation pattern induced by NMDA receptor antagonists

• Verfasst von: Inta, Ioana [VerfasserIn]
• Verfasst von: Sprengel, Rolf [VerfasserIn]
• Verfasst von: Bettendorf, Markus [VerfasserIn]
• Verfasst von: Inta, Dragos [VerfasserIn]
• Verfasst von: Gass, Peter [VerfasserIn]
• Titel: Puberty marks major changes in the hippocampal and cortical c-Fos activation pattern induced by NMDA receptor antagonists
• Verf.angabe: Ioana Inta, Emese Domonkos, Natascha Pfeiffer, Rolf Sprengel, Markus Bettendorf, Undine E. Lang, Dragos Inta, Peter Gass
• E-Jahr: 2017
• Jahr: January 2017
• Umfang: 7 S.
• Fussnoten: Gesehen am 29.03.2018
• Titel Quelle: Enthalten in: Neuropharmacology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1970
• Jahr Quelle: 2017
• Band/Heft Quelle: 112(2017), Seite 181-187
• ISSN Quelle: 1873-7064
• DOI: doi:10.1016/j.neuropharm.2016.03.023
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Cortex
• Sach-SW: Dentate gyrus
• Sach-SW: Gender
• Sach-SW: GluN2B
• Sach-SW: MK-801
• Sach-SW: Puberty
• K10plus-PPN: 1571623523

Abstract

Non-selective and subunit (GluN2B)-specific N-methyl-d-aspartate receptor (NMDAR) antagonists represent promising alternative antidepressant drugs with fast onset of the therapeutic action. The neuronal activation pattern induced by NMDAR antagonists is well characterized by c-Fos expression analysis only in the adult rodent brain. In contrast, there is little information available regarding their effects during postnatal development. Here we performed a systematic c-Fos brain mapping of the non-selective NMDAR antagonist MK-801 and the GluN2B-specific antagonist Ro 25-6981 from postnatal day 16 (P16) to P40. We found significant regional differences with gender-specificity in the activation pattern compared to the adult. Surprisingly, in the hippocampus, MK-801 triggered at pre-pubertal stages (especially at P24) very strong c-Fos expression, followed by low levels after P30, the approximate time point of puberty onset in mice. The cortical distribution of MK-801-triggered c-Fos expression before puberty differed also substantially from the adult brain, showing high levels only in deep cortical layers at pre-pubertal stages. In comparison, the cortical activation induced by Ro 25-6981 diminished from high pre-pubertal levels and was in comparison with that triggered by MK-801 low in the hippocampus. These results reveal highly dynamic changes in the c-Fos activation pattern induced by NMDAR antagonists during puberty. This article is part of the Special Issue entitled ‘Ionotropic glutamate receptors’.