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Verfasst von:Zimmermann, Johannes B. [VerfasserIn]   i
 Pinder, Nadine [VerfasserIn]   i
 Bruckner, Thomas [VerfasserIn]   i
 Lehmann, Monika [VerfasserIn]   i
 Motsch, Johann [VerfasserIn]   i
 Brenner, Thorsten [VerfasserIn]   i
 Hoppe-Tichy, Torsten [VerfasserIn]   i
 Swoboda, Stefanie [VerfasserIn]   i
 Weigand, Markus A. [VerfasserIn]   i
 Hofer, Stefan [VerfasserIn]   i
Titel:Adjunctive use of physostigmine salicylate (Anticholium®) in perioperative sepsis and septic shock
Titelzusatz:study protocol for a randomized, double-blind, placebo-controlled, monocentric trial (Anticholium® per Se)
Verf.angabe:Johannes B. Zimmermann, Nadine Pinder, Thomas Bruckner, Monika Lehmann, Johann Motsch, Thorsten Brenner, Torsten Hoppe-Tichy, Stefanie Swoboda, Markus A. Weigand and Stefan Hofer
E-Jahr:2017
Jahr:10 November 2017
Fussnoten:Gesehen am 04.04.2018
Titel Quelle:Enthalten in: Trials
Ort Quelle:London : BioMed Central, 2000
Jahr Quelle:2017
Band/Heft Quelle:18(2017) Artikel-Nummer 530, 10 Seiten
ISSN Quelle:1468-6694
 1745-6215
Abstract:Severe sepsis and septic shock remain a major challenge, even in modern intensive care. In Germany, about 68,000 patients die annually because of septic diseases, characterized by a complex systemic inflammatory response. Causal treatment of the underlying infection is essential for successful management of sepsis, but the course can be positively influenced by supportive and adjuvant measures. The cholinergic anti-inflammatory pathway (CAP) represents a new approach to adjunctive therapy of septic diseases and can be pharmacologically activated by the acetylcholinesterase inhibitor physostigmine (Anticholium®). Promising effects can be found in several in vitro and in vivo models of sepsis, such as a reduction in pro-inflammatory cytokines and improved survival.
DOI:doi:10.1186/s13063-017-2231-x
URL:kostenfrei: Volltext: http://dx.doi.org/10.1186/s13063-017-2231-x
 kostenfrei: Volltext: https://doi.org/10.1186/s13063-017-2231-x
 DOI: https://doi.org/10.1186/s13063-017-2231-x
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Antilirium
 Cholinergic anti-inflammatory pathway
 Cholinesterase inhibitor
 Continuous administration
 Critically ill
 Eserine
 Eseroline
 Intra-abdominal infection
 Physostigma venenosum
 Sequential Organ Failure Assessment (SOFA) score
K10plus-PPN:157169580X
Verknüpfungen:→ Zeitschrift
 
 
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