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| Verfasst von: | Büchel, Christian [VerfasserIn]  |
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| | Banaschewski, Tobias [VerfasserIn] |
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| | Flor, Herta [VerfasserIn] |
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| | Mann, Karl [VerfasserIn] |
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| | Poustka, Luise [VerfasserIn] |
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| | Rietschel, Marcella [VerfasserIn] |
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| Titel: | Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents |
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| Verf.angabe: | Christian Büchel, Jan Peters, Tobias Banaschewski, Arun L.W. Bokde, Uli Bromberg, Patricia J. Conrod, Herta Flor, Dimitri Papadopoulos, Hugh Garavan, Penny Gowland, Andreas Heinz, Henrik Walter, Bernd Ittermann, Karl Mann, Jean-Luc Martinot, Marie-Laure Paillère-Martinot, Frauke Nees, Tomas Paus, Zdenka Pausova, Luise Poustka, Marcella Rietschel, Trevor W. Robbins, Michael N. Smolka, Juergen Gallinat, Gunter Schumann, Brian Knutson and the IMAGEN Consortium |
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| E-Jahr: | 2017 |
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| Jahr: | 21 Feb 2017 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 04.04.2018 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Springer Nature, 2010 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 8(2017) Artikel-Nummer 14140, 11 Seiten |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Novelty-seeking tendencies in adolescents may promote innovation as well as problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated rewards promotes vulnerability in these individuals. Here we use a longitudinal design to track 144 novelty-seeking adolescents at age 14 and 16 to determine whether neural activity in response to anticipated rewards predicts problematic drug use. We find that diminished BOLD activity in mesolimbic (ventral striatal and midbrain) and prefrontal cortical (dorsolateral prefrontal cortex) regions during reward anticipation at age 14 predicts problematic drug use at age 16. Lower psychometric conscientiousness and steeper discounting of future rewards at age 14 also predicts problematic drug use at age 16, but the neural responses independently predict more variance than psychometric measures. Together, these findings suggest that diminished neural responses to anticipated rewards in novelty-seeking adolescents may increase vulnerability to future problematic drug use. |
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| DOI: | doi:10.1038/ncomms14140 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: http://dx.doi.org/10.1038/ncomms14140 |
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| | kostenfrei: Volltext: https://www.nature.com/articles/ncomms14140 |
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| | DOI: https://doi.org/10.1038/ncomms14140 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1571704981 |
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| Verknüpfungen: | → Zeitschrift |
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Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents / Büchel, Christian [VerfasserIn]; 21 Feb 2017 (Online-Ressource)
