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Verfasst von:Ait-Hsiko, Lamia [VerfasserIn]   i
 Wedel, Johannes [VerfasserIn]   i
 Yard, Benito A. [VerfasserIn]   i
 Bugert, Peter [VerfasserIn]   i
 Schedel, Angelika [VerfasserIn]   i
Titel:N-octanoyl-dopamine is a potent inhibitor of platelet function
Verf.angabe:Lamia Ait-Hsiko, Tineke Kraaij, Johannes Wedel, Bastian Theisinger, Sonja Theisinger, Benito Yard, Peter Bugert, Angelika Schedel
Umfang:7 S.
Fussnoten:Gesehen am 05.04.2018
Titel Quelle:Enthalten in: Platelets
Jahr Quelle:2013
Band/Heft Quelle:24(2013), 6, S. 428-434
ISSN Quelle:1369-1635
Abstract:Dopamine (DA) is a co-agonist for platelet activation; yet, donor DA treatment is associated with improved transplantation outcome in renal and heart recipients. Recently, N-octanoyl-dopamine (NOD) was developed which displays superior effects compared to DA in terms of graft protecting properties. Whereas DA is a known platelet co-agonist, the effect of NOD on platelet function is unknown. This is a hypothesis generating study with the aim to assess the effects and molecular mechanisms of NOD and NOD-like compounds on platelet function. The influence of DA, NOD, and NOD-like compounds on platelet responses to classical agonists (adenosine 5'-diphosphate (ADP), U46619) was investigated in six healthy donors by applying whole blood aggregometry (Multiplate®) and flow cytometry for Pac-1, CD62P, and CD63 expression. Changes in platelet cAMP concentrations were assessed by ELISA. While DA showed synergy in platelet activation by ADP and U46619, NOD caused significant inhibitionof platelet function both in whole blood aggregometry and flow cytometry. The inhibitory effect of NOD was not mediated via cAMP levels. The nonredox-active NOD-analog N-octanoyl-tyramine had no effects on platelet function. Acetylated NOD conferred to NOD by intracellular esterases showed similar inhibitory effects as NOD. In contrast to DA, NOD is a potent inhibitor of platelet function most likely through intracellular redox-active processes. This adds to the overall protective effect of NOD on pre-transplantation injury and makes NOD an attractive candidate compound for donor or organ conditioning prior to transplantation.
DOI:doi:10.3109/09537104.2012.715217
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Verlag: http://dx.doi.org/10.3109/09537104.2012.715217
 DOI: https://doi.org/10.3109/09537104.2012.715217
Datenträger:Online-Ressource
Sprache:eng
Bibliogr. Hinweis:Erscheint auch als Druck-Ausgabe: N-octanoyl-dopamine is a potent inhibitor of platelet function
K10plus-PPN:1571719490
Verknüpfungen:→ Zeitschrift

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