Osteoarthritis-patterns, cardio-metabolic risk factors and risk of all-cause mortality

• Verfasst von: Büchele, Gisela [VerfasserIn]
• Verfasst von: Brenner, Hermann [VerfasserIn]
• Titel: Osteoarthritis-patterns, cardio-metabolic risk factors and risk of all-cause mortality
• Titelzusatz: 20 years follow-up in patients after hip or knee replacement
• Verf.angabe: G. Büchele, K. P. Günther, H. Brenner, W. Puhl, T. Stürmer, D. Rothenbacher & R. E. Brenner
• E-Jahr: 2018
• Jahr: 27 March 2018
• Umfang: 8 S.
• Teil: volume:8
• Teil: year:2018
• Teil: extent:8
• Fussnoten: Gesehen am 05.04.2018
• Titel Quelle: Enthalten in: Scientific reports
• Ort Quelle: [London] : Macmillan Publishers Limited, part of Springer Nature, 2011
• Jahr Quelle: 2018
• Band/Heft Quelle: 8(2018) Artikel-Nummer 5253, 8 Seiten
• ISSN Quelle: 2045-2322
• DOI: doi:10.1038/s41598-018-23573-2
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1571720758

Abstract

Osteoarthritis (OA) is a common musculoskeletal disorder and occur in different patterns. However, its impact on long-term all-cause-mortality is inconclusive. Study aims: Investigate 20-year all-cause-mortality in patients with hip/knee arthroplasty (recruited 1995/1996, N = 809) from the Ulm Osteoarthritis Study-cohort, in comparison to general population. Furthermore, to enlighten the triangle between baseline life-style and cardio-metabolic risk factors, phenotypic OA-patterns (laterality, generalization, cause) and all-cause-mortality. Mortality was assessed during 20 years follow-up. Standardized mortality ratios (SMR), adjusted odds ratios and hazard ratios (aHR) were calculated. After five years cohort-mortality was reduced compared to the general population, however 20 years later assimilated (SMR = 1.11; 95%-CI 0.73-1.49). OA-patterns were associated with age, cholesterol, and overweight/obesity. In comparison to primary OA decreased mortality was observed for patients with secondary OA (aHR = 0.76; 95%-CI 0.61-0.95) adjusted for age, smoking, overweight/obesity, diabetes, hypertension, cardiac insufficiency, uric acid, and lower cholesterol. There was no increased mortality in patients after 20 years follow-up compared to general population. Significantly decreased mortality in secondary compared to primary OA suggests a subtype-specific involvement of systemic co-factors in determination of all-cause-mortality. Because cardio-metabolic risk factors were associated with increased risk of bilateral OA and lower long-term survival, those risk factors should be consequently targeted in OA-patients.