1,5-Anhydroglucitol als Marker kurzfristiger Blutzuckerspitzen

• Verfasst von: Kulozik, Felix [VerfasserIn]
• Verfasst von: Hasslacher, Christoph [VerfasserIn]
• Titel: 1,5-Anhydroglucitol als Marker kurzfristiger Blutzuckerspitzen
• Paralleltitel: 1,5-anhydroglucitol as a marker for short-term glycaemic excursions
• Verf.angabe: F. Kulozik, C. Hasslacher
• Jahr: 2015
• Umfang: 6 S.
• Fussnoten: Gesehen am 05.04.2018
• Titel Quelle: Enthalten in: Diabetes, Stoffwechsel und Herz
• Ort Quelle: Mainz : Kirchheim-Verlag, 2010
• Jahr Quelle: 2015
• Band/Heft Quelle: 24(2015), 2, Seite 89-94
• Datenträger: Online-Ressource
• Sprache: ger
• K10plus-PPN: 1571750045

Abstract

Background: The development of vascular diabetic complications depends on HbA1c levels as well as intermittent hyperglycaemic states. 1, 5-anhydroglucitol (1, 5-AG) is an established marker for short-term glycaemic excursions; the aim of this study was to analyse the correlation between 1, 5-AG and HbA1c as well as antidiabetic therapy. Methods: We analysed 1, 5-AG levels using an enzymatic test (GlycoMark®) alongside other parameters in 377 outpatients with type 2 diabetes. Results: 1, 5-AG decreased in correlation with increasing HbA1c levels. After classifying HbA1c levels into groups, a third of the patients with HbA1c < 6.5% and half of the patients with HbA1c 6.5-7.5 % showed significantly reduced levels of 1, 5-AG (≤ 5 μg/ml). Almost all of the patients with HbA1c >8.5% showed 1, 5-AG levels ≤ 5μg/ml. Conclusion: Measuring 1, 5-AG is an uncomplicated alternative to frequent postprandial and intermittent blood glucose (self) measurement or continuous glucose monitoring in addition to routine HbA1c testing in identifying type 2 diabetes patients with intermittent hyperglycaemia despite favourable HbA1c levels.