Is there evidence for statins in the treatment of aortic valve stenosis?

• Verfasst von: Akın, Ibrahim [VerfasserIn]
• Verfasst von: Nienaber, Christoph [VerfasserIn]
• Titel: Is there evidence for statins in the treatment of aortic valve stenosis?
• Verf.angabe: Ibrahim Akin, Christoph A. Nienaber
• E-Jahr: 2017
• Jahr: August 26, 2017
• Umfang: 8 S.
• Fussnoten: Gesehen am 11.04.2018
• Titel Quelle: Enthalten in: World journal of cardiology
• Ort Quelle: Hong Kong : Baishideng Publ., 2009
• Jahr Quelle: 2017
• Band/Heft Quelle: 9(2017), 8, Seite 667-672
• ISSN Quelle: 1949-8462
• DOI: doi:10.4330/wjc.v9.i8.667
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Aortic stenosis
• Sach-SW: Aortic valve surgery
• Sach-SW: Coronary artery stenosis
• Sach-SW: HMG-CoA enzyme inhibitor
• Sach-SW: Statins
• K10plus-PPN: 1571922857

Abstract

Research revealed that the pathogenesis of aortic stenosis (AS) not merely comprises of a mechanical wear and tear process yet that active biological processes, similar to those of coronary artery disease are involved, a promising role for statins in disease-modifying therapy was suggested. However, recently, many prospective studies could not observe decreased progression nor regression of the disease. Here, we review the current knowledge on the pathomechanisms of AS and its similarities and differences with atherosclerosis. Moreover, we discuss whether there is still a place for statins in the treatment of particular AS patient subgroups.