Magnolol inhibits venous remodeling in mice

• Verfasst von: Kuk, Hanna [VerfasserIn]
• Verfasst von: Arnold, Caroline [VerfasserIn]
• Verfasst von: Hecker, Markus [VerfasserIn]
• Verfasst von: Korff, Thomas [VerfasserIn]
• Titel: Magnolol inhibits venous remodeling in mice
• Verf.angabe: Hanna Kuk, Caroline Arnold, Ralph Meyer, Markus Hecker & Thomas Korff
• E-Jahr: 2017
• Jahr: 19 December 2017
• Umfang: 13 S.
• Fussnoten: Gesehen am 12.04.2018
• Titel Quelle: Enthalten in: Scientific reports
• Ort Quelle: [London] : Macmillan Publishers Limited, part of Springer Nature, 2011
• Jahr Quelle: 2017
• Band/Heft Quelle: 7(2017) Artikel-Nummer 17820, 13 Seiten
• ISSN Quelle: 2045-2322
• DOI: doi:10.1038/s41598-017-17910-0
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1571976175
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Due to gravity the venous vasculature in the lower extremities is exposed to elevated pressure levels which may be amplified by obesity or pregnancy. As a consequence, venules dilate and may be slowly transformed into varicose or spider veins. In fact, chronically elevated venous pressure was sufficient to cause the corkscrew-like enlargement of superficial veins in mice. We hypothesized that biomechanical activation of endothelial cells contributes to this process and investigated the inhibitory capacity of Magnolol in this context - a natural compound that features multiple properties counteracting cellular stress. While Magnolol did not influence endothelial capillary sprout formation, it interfered with proliferation, ERK1/2 activity, gelatinase activity as well as baseline production of reactive oxygen species in these cells or murine veins. The anti-oxidative and anti-proliferative capacity of Magnolol was mediated through stimulation of heme oxygenase-1 expression. Finally, local transdermal application of Magnolol attenuated pressure-mediated development of varicose/spider veins in mice and was accompanied by the absence of proliferating and MMP-2 positive endothelial cells. Collectively, our data identified Magnolol as a potent inhibitor of biomechanically evoked endothelial cell activity during pressure-mediated venous remodeling processes which contribute to the development of varicose and spider veins.