Multidrug‐resistant organisms in allogeneic hematopoietic cell transplantation

• Verfasst von: Heidenreich, Daniela [VerfasserIn]
• Verfasst von: Kreil, Sebastian [VerfasserIn]
• Verfasst von: Nolte, Florian [VerfasserIn]
• Verfasst von: Hofmann, Wolf-Karsten [VerfasserIn]
• Verfasst von: Miethke, Thomas [VerfasserIn]
• Verfasst von: Klein, Stefan [VerfasserIn]
• Titel: Multidrug‐resistant organisms in allogeneic hematopoietic cell transplantation
• Verf.angabe: Daniela Heidenreich, Sebastian Kreil, Florian Nolte, Wolf K. Hofmann, Thomas Miethke,Stefan A. Klein
• E-Jahr: 2017
• Jahr: 30 January 2017
• Umfang: 8 S.
• Fussnoten: Gesehen am 12.04.2018
• Titel Quelle: Enthalten in: European journal of haematology
• Ort Quelle: Oxford : Wiley-Blackwell, 1987
• Jahr Quelle: 2017
• Band/Heft Quelle: 98(2017), 5, Seite 485-492
• ISSN Quelle: 1600-0609
• DOI: doi:10.1111/ejh.12859
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: allogeneic hematopoietic cell transplantation
• Sach-SW: colonization
• Sach-SW: infection
• Sach-SW: multidrug‐resistant organisms
• Sach-SW: multidrug‐resistant Pseudomonas aeruginosa
• K10plus-PPN: 1571944516

Abstract

Abstract: Objective multidrug-resistant organisms (MDRO) are a challenge in allogeneic hematopoietic cell transplantation (HCT). However, in the literature there is no comprehensive analysis on MDRO in HCT. In this retrospective, single-center analysis, we appraised prevalence and clinical impact of MDRO in 98 consecutive allogeneic HCT patients. Method: Prior to the conditioning (baseline) and whenever clinically indicated patients underwent a full screening for MDRO (stool and urine cultures, swabs from several body regions). Results: It turned out that 26 patients were colonized by 33 MDRO, either at baseline (n=16) or at any other time until day 100 post?transplantation. Of these 26 patients, eight developed an infection with MDRO, four of them by 4MRGN Pseudomonas aeruginosa, and three of them died MDRO-related. However, there was no significant difference between MDRO-colonized and non-colonized patients regarding overall survival (OS) and non-relapse-mortality (NRM). There was only a trend toward a higher NRM in patients already colonized by MDRO at baseline. This was due to the high NRM in multidrug-resistant P. aeruginosa-colonized patients. Conclusion: In summary, colonization with MDRO other than P. aeruginosa had no negative impact on NRM and OS. Patients colonized by multidrug-resistant P. aeruginosa had a dismal outcome. HCT of these patients should be considered with care. Screening for MDRO in the pretransplant work-up is suggested.