Calcium handling and atrial fibrillation

• Verfasst von: Heijman, Jordi [VerfasserIn]
• Verfasst von: Voigt, Niels [VerfasserIn]
• Verfasst von: Dobrev, Dobromir [VerfasserIn]
• Titel: Calcium handling and atrial fibrillation
• Verf.angabe: Jordi Heijman, Niels Voigt, Stanley Nattel, Dobromir Dobrev
• E-Jahr: 2012
• Jahr: 14 June 2012
• Umfang: 5 S.
• Fussnoten: Gesehen am 12.04.2018
• Titel Quelle: Enthalten in: Wiener medizinische Wochenschrift
• Ort Quelle: [Erscheinungsort nicht ermittelbar] : Blackwell-Wiley, 2002
• Jahr Quelle: 2012
• Band/Heft Quelle: 162(2012), 13-14, Seite 287-291
• ISSN Quelle: 1563-258X
• DOI: doi:10.1007/s10354-012-0109-9
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1571949429

Abstract

Summary: Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia in the clinical setting. It is associated with substantial cardiovascular morbidity and mortality. Recent research has indicated that abnormal Ca2+ handling plays a critical role in the induction and maintenance of AF, contributing to ectopic activity, AF-maintaining reentry circuits and related prothrombotic atrial hypocontractility. The AF-specific Ca2+-handling abnormalities may constitute viable therapeutic approaches to treat AF. Here, we review the causes, consequences, and therapeutic implications of altered atrial Ca2+ handling for AF pathophysiology.