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Status: Bibliographieeintrag

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Verfasst von:Nees, Frauke [VerfasserIn]   i
 Vollstädt-Klein, Sabine [VerfasserIn]   i
 Poustka, Luise [VerfasserIn]   i
 Banaschewski, Tobias [VerfasserIn]   i
 Mann, Karl [VerfasserIn]   i
 Rietschel, Marcella [VerfasserIn]   i
 Spanagel, Rainer [VerfasserIn]   i
 Flor, Herta [VerfasserIn]   i
Titel:Determinants of early alcohol use In healthy adolescents
Titelzusatz:the differential contribution of neuroimaging and psychological factors
Verf.angabe:Frauke Nees, Jelka Tzschoppe, Christopher J. Patrick, Sabine Vollstädt-Klein, Sabina Steiner, Luise Poustka, Tobias Banaschewski, Gareth J. Barker, Christian Büchel, Patricia J. Conrod, Hugh Garavan, Andreas Heinz, Jürgen Gallinat, Mark Lathrop, Karl Mann, Eric Artiges, Tomas Paus, Jean-Baptiste Poline, Trevor W. Robbins, Marcella Rietschel, Michael N. Smolka, Rainer Spanagel, Maren Struve, Eva Loth, Gunter Schumann and Herta Flor, the IMAGEN Consortium
E-Jahr:2012
Jahr:23 November 2011
Jahr des Originals:2011
Umfang:10 S.
Fussnoten:Gesehen am 12.04.2018
Titel Quelle:Enthalten in: Neuropsychopharmacology
Ort Quelle:London : Springer Nature, 1993
Jahr Quelle:2012
Band/Heft Quelle:37(2012), 4, Seite 986-995
ISSN Quelle:1740-634X
Abstract:Individual variation in reward sensitivity may have an important role in early substance use and subsequent development of substance abuse. This may be especially important during adolescence, a transition period marked by approach behavior and a propensity toward risk taking, novelty seeking and alteration of the social landscape. However, little is known about the relative contribution of personality, behavior, and brain responses for prediction of alcohol use in adolescents. In this study, we applied factor analyses and structural equation modeling to reward-related brain responses assessed by functional magnetic resonance imaging during a monetary incentive delay task. In addition, novelty seeking, sensation seeking, impulsivity, extraversion, and behavioral measures of risk taking were entered as predictors of early onset of drinking in a sample of 14-year-old healthy adolescents (N=324). Reward-associated behavior, personality, and brain responses all contributed to alcohol intake with personality explaining a higher proportion of the variance than behavior and brain responses. When only the ventral striatum was used, a small non-significant contribution to the prediction of early alcohol use was found. These data suggest that the role of reward-related brain activation may be more important in addiction than initiation of early drinking, where personality traits and reward-related behaviors were more significant. With up to 26% of explained variance, the interrelation of reward-related personality traits, behavior, and neural response patterns may convey risk for later alcohol abuse in adolescence, and thus may be identified as a vulnerability factor for the development of substance use disorders.
DOI:doi:10.1038/npp.2011.282
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

teilw. kostenfrei: Volltext: http://dx.doi.org/10.1038/npp.2011.282
 teilw. kostenfrei: Volltext: https://www-nature-com.ezproxy.medma.uni-heidelberg.de/articles/npp2011282
 DOI: https://doi.org/10.1038/npp.2011.282
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1571971947
Verknüpfungen:→ Zeitschrift

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