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Verfasst von:Schirmbeck, Frederike [VerfasserIn]   i
 Zink, Mathias [VerfasserIn]   i
Titel:Clozapine-induced obsessive-compulsive symptoms in schizophrenia
Titelzusatz:a critical review
Verf.angabe:Frederike Schirmbeck and Mathias Zink
Jahr:2012
Umfang:8 S.
Fussnoten:Gesehen am:12.04.2018
Titel Quelle:Enthalten in: Current neuropharmacology
Ort Quelle:Hilversum [u.a.] : Bentham Science Publ., 2003
Jahr Quelle:2012
Band/Heft Quelle:10(2012), 1, Seite 88-95
ISSN Quelle:1875-6190
Abstract:Obsessive-compulsive disorder (OCD) is rarely associated with schizophrenia, whereas 20 to 30% of schizophrenic patients, suffer from comorbid obsessive-compulsive symptoms (OCS). So far no single pathogenetic theory convincingly explained this fact suggesting heterogeneous subgroups. Based on long-term case observations, one hypothesis assumes that second-onset OCS in the course of schizophrenia might be a side effect of second generation antipsychotics (SGA), most importantly clozapine (CLZ). This review summarizes the supporting epidemiological and pharmacological evidence: Estimations on prevalence of OCS increase in more recent cross-sectional studies and in later disease stages. Longitudinal observations report the de novo-onset of OCS under clozapine treatment. This association has not been reported with first generation antipsychotics (FGA) or SGAs with mainly dopaminergic mode of action. Finally, significant correlations of OCS-severity with duration of treatment, dose and serum levels suggest clozapine-induced OCS. However, supposed causal interactions need further verifications. It is also unclear, which neurobiological mechanisms might underlie the pathogenetic process. Detailed genotypic and phenotypic characterizations of schizophrenics with comorbid OCS regarding neurocognitive functioning and activation in sensitive tasks of functional magnetic imaging are needed. Multimodal large-scaled prospective studies are necessary to define patients at risk for second-onset OCS and to improve early detection and therapeutic interventions.
DOI:doi:10.2174/157015912799362724
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

teilw. kostenfrei: Volltext: http://dx.doi.org/10.2174/157015912799362724
 teilw. kostenfrei: Volltext: http://www.eurekaselect.com.ezproxy.medma.uni-heidelberg.de/76577/article
 DOI: https://doi.org/10.2174/157015912799362724
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1571975055
Verknüpfungen:→ Zeitschrift

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