Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Westerhausen, Christoph [VerfasserIn]  |
| Bauer, Alexander [VerfasserIn]  |
| Schneider, Stefan W. [VerfasserIn]  |
Titel: | Chemical and mechanical impact of silica nanoparticles on the phase transition behavior of phospholipid membranes in theory and experiment |
Verf.angabe: | C. Westerhausen, F.G. Strobl, R. Herrmann, A.T. Bauer, S.W. Schneider, A. Reller, A. Wixforth, M.F. Schneider |
E-Jahr: | 2012 |
Jahr: | 7 March 2012 |
Umfang: | 7 S. |
Fussnoten: | Gesehen am 16.04.2018 |
Titel Quelle: | Enthalten in: Biophysical journal |
Ort Quelle: | Cambridge, Mass. : Cell Press, 1960 |
Jahr Quelle: | 2012 |
Band/Heft Quelle: | 102(2012), 5, Seite 1032-1038 |
ISSN Quelle: | 1542-0086 |
Abstract: | The interaction of nanoparticles (NPs) with lipid membranes is an integral step in the interaction of NPs and living cells. During particle uptake, the membrane has to bend. Due to the nature of their phase diagram, the modulus of compression of these membranes can vary by more than one order of magnitude, and thus both the thermodynamic and mechanical aspects of the membrane have to be considered simultaneously. We demonstrate that silica NPs have at least two independent effects on the phase transition of phospholipid membranes: 1), a chemical effect resulting from the finite instability of the NPs in water; and 2), a mechanical effect that originates from a bending of the lipid membrane around the NPs. Here, we report on recent experiments that allowed us to clearly distinguish both effects, and present a thermodynamic model that includes the elastic energy of the membranes and correctly predicts our findings both quantitatively and qualitatively. |
DOI: | doi:10.1016/j.bpj.2011.12.004 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: http://dx.doi.org/10.1016/j.bpj.2011.12.004 |
| kostenfrei: Volltext: http://www.sciencedirect.com/science/article/pii/S0006349511053707 |
| DOI: https://doi.org/10.1016/j.bpj.2011.12.004 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1572036001 |
Verknüpfungen: | → Zeitschrift |
Chemical and mechanical impact of silica nanoparticles on the phase transition behavior of phospholipid membranes in theory and experiment / Westerhausen, Christoph [VerfasserIn]; 7 March 2012 (Online-Ressource)
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