| Online-Ressource |
Verfasst von: | Steringer, Julia Pauline [VerfasserIn]  |
| Zacherl, Sonja [VerfasserIn]  |
| Andreas, Helena [VerfasserIn]  |
| Laußmann, Mareike [VerfasserIn]  |
| Temmerman, Koen [VerfasserIn]  |
| Contreras, F. Xabier [VerfasserIn]  |
| Lechner, Johannes [VerfasserIn]  |
| Müller, Hans-Michael [VerfasserIn]  |
| García-Sáez, Ana J. [VerfasserIn]  |
| Nickel, Walter [VerfasserIn]  |
Titel: | Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-dependent oligomerization of fibroblast growth factor 2 (FGF2) triggers the formation of a lipidic membrane pore implicated in unconventional secretion |
Verf.angabe: | Julia P. Steringer, Stephanie Bleicken, Helena Andreas, Sonja Zacherl, Mareike Laussmann, Koen Temmerman, F. Xabier Contreras, Tanmay A.M. Bharat, Johannes Lechner, Hans-Michael Müller, John A.G. Briggs, Ana J. García-Sáez, and Walter Nickel |
Umfang: | 12 S. |
Fussnoten: | Gesehen am 16.04.2018 ; Im Titel ist bei (PI(4,5)P2) die Ziffer "2" tiefgestellt |
Titel Quelle: | Enthalten in: The journal of biological chemistry |
Jahr Quelle: | 2012 |
Band/Heft Quelle: | 287(2012), 33, S. 27659-27669 |
ISSN Quelle: | 1083-351X |
Abstract: | Fibroblast growth factor 2 (FGF2) is a critical mitogen with a central role in specific steps of tumor-induced angiogenesis. It is known to be secreted by unconventional means bypassing the endoplasmic reticulum/Golgi-dependent secretory pathway. However, the mechanism of FGF2 membrane translocation into the extracellular space has remained elusive. Here, we show that phosphatidylinositol 4,5-bisphosphate-dependent membrane recruitment causes FGF2 to oligomerize, which in turn triggers the formation of a lipidic membrane pore with a putative toroidal structure. This process is strongly up-regulated by tyrosine phosphorylation of FGF2. Our findings explain key requirements of FGF2 secretion from living cells and suggest a novel self-sustained mechanism of protein translocation across membranes with a lipidic membrane pore being a transient translocation intermediate. |
DOI: | doi:10.1074/jbc.M112.381939 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Verlag: http://dx.doi.org/10.1074/jbc.M112.381939 |
| Verlag: http://www.jbc.org/content/287/33/27659 |
| DOI: https://doi.org/10.1074/jbc.M112.381939 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1572050586 |
Verknüpfungen: | → Zeitschrift |
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-dependent oligomerization of fibroblast growth factor 2 (FGF2) triggers the formation of a lipidic membrane pore implicated in unconventional secretion / Steringer, Julia Pauline [VerfasserIn] (Online-Ressource)