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| Verfasst von: | Steringer, Julia Pauline [VerfasserIn]  |
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| | Zacherl, Sonja [VerfasserIn] |
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| | Andreas, Helena [VerfasserIn] |
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| | Laußmann, Mareike [VerfasserIn] |
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| | Temmerman, Koen [VerfasserIn] |
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| | Contreras, F. Xabier [VerfasserIn] |
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| | Lechner, Johannes [VerfasserIn] |
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| | Müller, Hans-Michael [VerfasserIn] |
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| | García-Sáez, Ana J. [VerfasserIn] |
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| | Nickel, Walter [VerfasserIn] |
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| Titel: | Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-dependent oligomerization of fibroblast growth factor 2 (FGF2) triggers the formation of a lipidic membrane pore implicated in unconventional secretion |
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| Verf.angabe: | Julia P. Steringer, Stephanie Bleicken, Helena Andreas, Sonja Zacherl, Mareike Laussmann, Koen Temmerman, F. Xabier Contreras, Tanmay A.M. Bharat, Johannes Lechner, Hans-Michael Müller, John A.G. Briggs, Ana J. García-Sáez, and Walter Nickel |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 16.04.2018 ; Im Titel ist bei (PI(4,5)P2) die Ziffer "2" tiefgestellt |
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| Titel Quelle: | Enthalten in: The journal of biological chemistry |
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| Jahr Quelle: | 2012 |
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| Band/Heft Quelle: | 287(2012), 33, S. 27659-27669 |
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| ISSN Quelle: | 1083-351X |
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| Abstract: | Fibroblast growth factor 2 (FGF2) is a critical mitogen with a central role in specific steps of tumor-induced angiogenesis. It is known to be secreted by unconventional means bypassing the endoplasmic reticulum/Golgi-dependent secretory pathway. However, the mechanism of FGF2 membrane translocation into the extracellular space has remained elusive. Here, we show that phosphatidylinositol 4,5-bisphosphate-dependent membrane recruitment causes FGF2 to oligomerize, which in turn triggers the formation of a lipidic membrane pore with a putative toroidal structure. This process is strongly up-regulated by tyrosine phosphorylation of FGF2. Our findings explain key requirements of FGF2 secretion from living cells and suggest a novel self-sustained mechanism of protein translocation across membranes with a lipidic membrane pore being a transient translocation intermediate. |
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| DOI: | doi:10.1074/jbc.M112.381939 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Verlag: http://dx.doi.org/10.1074/jbc.M112.381939 |
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| | Verlag: http://www.jbc.org/content/287/33/27659 |
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| | DOI: https://doi.org/10.1074/jbc.M112.381939 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1572050586 |
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| Verknüpfungen: | → Zeitschrift |
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Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-dependent oligomerization of fibroblast growth factor 2 (FGF2) triggers the formation of a lipidic membrane pore implicated in unconventional secretion / Steringer, Julia Pauline [VerfasserIn] (Online-Ressource)
