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Verfasst von:Zhao, Zhihan [VerfasserIn]   i
 Lan, Huan [VerfasserIn]   i
 El-Battrawy, Ibrahim [VerfasserIn]   i
 Buljubasic, Fanis [VerfasserIn]   i
 Sattler, Katherine [VerfasserIn]   i
 Yücel, Gökhan [VerfasserIn]   i
 Lang, Siegfried [VerfasserIn]   i
 Utikal, Jochen [VerfasserIn]   i
 Wieland, Thomas [VerfasserIn]   i
 Borggrefe, Martin [VerfasserIn]   i
 Zhou, Xiao-Bo [VerfasserIn]   i
 Akın, Ibrahim [VerfasserIn]   i
Titel:Ion channel expression and characterization in human induced pluripotent stem cell-derived cardiomyocytes
Verf.angabe:Zhihan Zhao, Huan Lan, Ibrahim El-Battrawy, Xin Li, Fanis Buljubasic, Katherine Sattler, Gökhan Yücel, Siegfried Lang, Malte Tiburcy, Wolfram-Hubertus Zimmermann, Lukas Cyganek, Jochen Utikal, Thomas Wieland, Martin Borggrefe, Xiao-Bo Zhou, and Ibrahim Akin
E-Jahr:2018
Jahr:8 January 2018
Fussnoten:Gesehen am 17.04.2018
Titel Quelle:Enthalten in: Stem cells international
Ort Quelle:London [u.a.] : Sage-Hindawi, 2010
Jahr Quelle:2018
Band/Heft Quelle:(2017) Artikel-Nummer 6067096, 14 Seiten
ISSN Quelle:1687-9678
Abstract:Background. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are providing new possibilities for the biological study, cell therapies, and drug discovery. However, the ion channel expression and functions as well as regulations in hiPSC-CMs still need to be fully characterized. Methods. Cardiomyocytes were derived from hiPS cells that were generated from two healthy donors. qPCR and patch clamp techniques were used for the study. Results. In addition to the reported ion channels, INa, ICa-L, ICa-T, If, INCX, IK1, Ito, IKr, IKs IKATP, IK-pH, ISK1-3, and ISK4, we detected both the expression and currents of ACh-activated (KACh) and Na
DOI:doi:10.1155/2018/6067096
URL:kostenfrei: Volltext: http://dx.doi.org/10.1155/2018/6067096
 kostenfrei: Volltext: https://www.hindawi.com/journals/sci/2018/6067096/
 DOI: https://doi.org/10.1155/2018/6067096
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1572100702
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