Global slowing of network oscillations in mouse neocortex by diazepam

• Verfasst von: Scheffzük, Claudia [VerfasserIn]
• Verfasst von: Draguhn, Andreas [VerfasserIn]
• Verfasst von: Brankačk, Jurij [VerfasserIn]
• Titel: Global slowing of network oscillations in mouse neocortex by diazepam
• Verf.angabe: Claudia Scheffzük, Valeriy I. Kukushka, Alexei L. Vyssotski, Andreas Draguhn, Adriano B.L. Tort, Jurij Brankačk
• Jahr: 2013
• Umfang: 11 S.
• Illustrationen: Illustrationen
• Fussnoten: Online veröffentlicht: 9. Oktober 2012 ; Gesehen am 16.12.2024
• Titel Quelle: Enthalten in: Neuropharmacology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1970
• Jahr Quelle: 2013
• Band/Heft Quelle: 65(2013) vom: Feb., Seite 123-133
• ISSN Quelle: 1873-7064
• DOI: doi:10.1016/j.neuropharm.2012.09.014
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: In vivo electrophysiology
• Sach-SW: Local field potential
• Sach-SW: Neuronal oscillations
• Sach-SW: Brain rhythms
• Sach-SW: Sleep-wake cycle
• Sach-SW: Cross-frequency coupling
• K10plus-PPN: 1572109289

Abstract

Benzodiazepines have a broad spectrum of clinical applications including sedation, anti-anxiety, and anticonvulsive therapy. At the cellular level, benzodiazepines are allosteric modulators of GABA(A) receptors; they increase the efficacy of inhibition in neuronal networks by prolonging the duration of inhibitory postsynaptic potentials. This mechanism of action predicts that benzodiazepines reduce the frequency of inhibition-driven network oscillations, consistent with observations from human and animal EEG. However, most of existing data are restricted to frequency bands below ∼30 Hz. Recent data suggest that faster cortical network rhythms are critically involved in several behavioral and cognitive tasks. We therefore analyzed diazepam effects on a large range of cortical network oscillations in freely moving mice, including theta (4-12 Hz), gamma (40-100 Hz) and fast gamma (120-160 Hz) oscillations. We also investigated diazepam effects over the coupling between theta phase and the amplitude fast oscillations. We report that diazepam causes a global slowing of oscillatory activity in all frequency domains. Oscillation power was changed differently for each frequency domain, with characteristic differences between active wakefulness, slow-wave sleep and REM sleep. Cross-frequency coupling strength, in contrast, was mostly unaffected by diazepam. Such state- and frequency-dependent actions of benzodiazepines on cortical network oscillations may be relevant for their specific cognitive effects. They also underline the strong interaction between local network oscillations and global brain states.