Long-term course of brain-derived neurotrophic factor serum levels in a patient treated with deep brain stimulation of the lateral habenula

• Verfasst von: Hoyer, Carolin [VerfasserIn]
• Verfasst von: Sartorius, Alexander [VerfasserIn]
• Verfasst von: Gass, Peter [VerfasserIn]
• Titel: Long-term course of brain-derived neurotrophic factor serum levels in a patient treated with deep brain stimulation of the lateral habenula
• Verf.angabe: Carolin Hoyer, Laura Kranaster, Alexander Sartorius, Rainer Hellweg, Peter Gass
• E-Jahr: 2012
• Jahr: February 25, 2012
• Umfang: 6 S.
• Fussnoten: Gesehen am 18.04.2018
• Titel Quelle: Enthalten in: Neuropsychobiology
• Ort Quelle: Basel : Karger, 1975
• Jahr Quelle: 2012
• Band/Heft Quelle: 65(2012), 3, Seite 147-152
• ISSN Quelle: 1423-0224
• DOI: doi:10.1159/000335243
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1572121874

Abstract

Introduction: According to the neurotrophin hypothesis, a brain-derived neurotrophic factor (BDNF) decrease has been postulated as a pivotal pathomechanism in affective disorder, and the treatment-associated increase in peripheral BDNF has been linked to therapeutic efficacy of antidepressant drugs and electroconvulsive therapy. However, in deep brain stimulation (DBS), a still experimental antidepressant treatment approach, this issue has not yet been investigated. Methods: We examine the long-term course of serum BDNF levels in a 64-year-old woman who is being treated with DBS of the lateral habenula for severe major depressive disorder. Results: Our main findings are a significant increase in BDNF serum levels following DBS of the lateral habenula and an inverse U-shaped correlation of depression scores and BDNF levels. Discussion: The data indicate that DBS, like other effective antidepressant treatments, may contribute to an increase in peripheral BDNF levels, which are thought to reflect central nervous DBS-induced neuroplastic changes. Moreover, our observations underscore the complex nature of disease-associated BDNF alterations. Their identification as either state or trait marker remains controversial and requires larger-scale longitudinal studies.