Status: Bibliographieeintrag
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| Online-Ressource |
Verfasst von: | Hoyer, Carolin [VerfasserIn]  |
| Sartorius, Alexander [VerfasserIn]  |
| Gass, Peter [VerfasserIn]  |
Titel: | Long-term course of brain-derived neurotrophic factor serum levels in a patient treated with deep brain stimulation of the lateral habenula |
Verf.angabe: | Carolin Hoyer, Laura Kranaster, Alexander Sartorius, Rainer Hellweg, Peter Gass |
E-Jahr: | 2012 |
Jahr: | February 25, 2012 |
Umfang: | 6 S. |
Fussnoten: | Gesehen am 18.04.2018 |
Titel Quelle: | Enthalten in: Neuropsychobiology |
Ort Quelle: | Basel : Karger, 1975 |
Jahr Quelle: | 2012 |
Band/Heft Quelle: | 65(2012), 3, Seite 147-152 |
ISSN Quelle: | 1423-0224 |
Abstract: | Introduction: According to the neurotrophin hypothesis, a brain-derived neurotrophic factor (BDNF) decrease has been postulated as a pivotal pathomechanism in affective disorder, and the treatment-associated increase in peripheral BDNF has been linked to therapeutic efficacy of antidepressant drugs and electroconvulsive therapy. However, in deep brain stimulation (DBS), a still experimental antidepressant treatment approach, this issue has not yet been investigated. Methods: We examine the long-term course of serum BDNF levels in a 64-year-old woman who is being treated with DBS of the lateral habenula for severe major depressive disorder. Results: Our main findings are a significant increase in BDNF serum levels following DBS of the lateral habenula and an inverse U-shaped correlation of depression scores and BDNF levels. Discussion: The data indicate that DBS, like other effective antidepressant treatments, may contribute to an increase in peripheral BDNF levels, which are thought to reflect central nervous DBS-induced neuroplastic changes. Moreover, our observations underscore the complex nature of disease-associated BDNF alterations. Their identification as either state or trait marker remains controversial and requires larger-scale longitudinal studies. |
DOI: | doi:10.1159/000335243 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1159/000335243 |
| Volltext: https://www-karger-com.ezproxy.medma.uni-heidelberg.de/Article/FullText/335243 |
| DOI: https://doi.org/10.1159/000335243 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1572121874 |
Verknüpfungen: | → Zeitschrift |
Long-term course of brain-derived neurotrophic factor serum levels in a patient treated with deep brain stimulation of the lateral habenula / Hoyer, Carolin [VerfasserIn]; February 25, 2012 (Online-Ressource)
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