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Status: Bibliographieeintrag

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Verfasst von:Hoyer, Carolin [VerfasserIn]   i
 Sartorius, Alexander [VerfasserIn]   i
 Gass, Peter [VerfasserIn]   i
Titel:Long-term course of brain-derived neurotrophic factor serum levels in a patient treated with deep brain stimulation of the lateral habenula
Verf.angabe:Carolin Hoyer, Laura Kranaster, Alexander Sartorius, Rainer Hellweg, Peter Gass
E-Jahr:2012
Jahr:February 25, 2012
Umfang:6 S.
Fussnoten:Gesehen am 18.04.2018
Titel Quelle:Enthalten in: Neuropsychobiology
Ort Quelle:Basel : Karger, 1975
Jahr Quelle:2012
Band/Heft Quelle:65(2012), 3, Seite 147-152
ISSN Quelle:1423-0224
Abstract:Introduction: According to the neurotrophin hypothesis, a brain-derived neurotrophic factor (BDNF) decrease has been postulated as a pivotal pathomechanism in affective disorder, and the treatment-associated increase in peripheral BDNF has been linked to therapeutic efficacy of antidepressant drugs and electroconvulsive therapy. However, in deep brain stimulation (DBS), a still experimental antidepressant treatment approach, this issue has not yet been investigated. Methods: We examine the long-term course of serum BDNF levels in a 64-year-old woman who is being treated with DBS of the lateral habenula for severe major depressive disorder. Results: Our main findings are a significant increase in BDNF serum levels following DBS of the lateral habenula and an inverse U-shaped correlation of depression scores and BDNF levels. Discussion: The data indicate that DBS, like other effective antidepressant treatments, may contribute to an increase in peripheral BDNF levels, which are thought to reflect central nervous DBS-induced neuroplastic changes. Moreover, our observations underscore the complex nature of disease-associated BDNF alterations. Their identification as either state or trait marker remains controversial and requires larger-scale longitudinal studies.
DOI:doi:10.1159/000335243
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1159/000335243
 Volltext: https://www-karger-com.ezproxy.medma.uni-heidelberg.de/Article/FullText/335243
 DOI: https://doi.org/10.1159/000335243
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1572121874
Verknüpfungen:→ Zeitschrift

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