Zwitterionic near infrared fluorescent agents for noninvasive real-time transcutaneous assessment of kidney function

• Verfasst von: Huang, Jiaguo [VerfasserIn]
• Verfasst von: Weinfurter, Stefanie [VerfasserIn]
• Verfasst von: Daniele, Cristina [VerfasserIn]
• Verfasst von: Pill, Johannes [VerfasserIn]
• Verfasst von: Gretz, Norbert [VerfasserIn]
• Titel: Zwitterionic near infrared fluorescent agents for noninvasive real-time transcutaneous assessment of kidney function
• Verf.angabe: Jiaguo Huang, Stefanie Weinfurter, Cristina Daniele, Rossana Perciaccante, Rodeghiero Federica, Leopoldo Della Ciana, Johannes Pill and Norbert Gretz
• E-Jahr: 2017
• Jahr: 11 Jan 2017
• Umfang: 9 S.
• Fussnoten: Gesehen am 18.04.2018
• Titel Quelle: Enthalten in: Chemical science
• Ort Quelle: Cambridge : RSC, 2010
• Jahr Quelle: 2017
• Band/Heft Quelle: 8(2017), 4, Seite 2652-2660
• ISSN Quelle: 2041-6539
• DOI: doi:10.1039/C6SC05059J
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1572123869

Abstract

We developed novel zwitterionic near infrared (NIR) fluorescent agents (ABZWCY-HPβCD and AAZWCY-HPβCD), which exhibit favorable hydrophilicity, low plasma protein binding, high stability and non-toxicity. These attractive characteristics ensure that they are excreted rapidly, without any skin accumulation or metabolism in vivo. More importantly, zwitterionic HPβCD based agents can be efficiently filtrated by the glomerulus and completely excreted through the kidneys into urine without reabsorption or secretion in the kidney proximal tubule. Relying on these novel zwitterionic NIR agents and a transcutaneous device, we demonstrate a rapid, robust and biocompatible approach for assessing kidney function in rat models of both healthy rats and those with kidney disease, without the need for time-consuming blood/urine sample preparation. Our work provides a promising tool for in vivo real-time non-invasive kidney function assessment in preclinical applications.