Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Alexander, Nina Carmen [VerfasserIn]  |
| Koppe, Georgia [VerfasserIn]  |
Titel: | Interaction of the serotonin transporter-linked polymorphic region and environmental adversity |
Titelzusatz: | increased amygdala-hypothalamus connectivity as a potential mechanism linking neural and endocrine hyperreactivity |
Verf.angabe: | Nina Alexander, Tim Klucken, Georgia Koppe, Roman Osinsky, Bertram Walter, Dieter Vaitl, Gebhard Sammer, Rudolf Stark, and Juergen Hennig |
E-Jahr: | 2012 |
Jahr: | 12 March 2012 |
Umfang: | 8 S. |
Fussnoten: | Gesehen am 23.04.2018 |
Titel Quelle: | Enthalten in: Biological psychiatry |
Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1985 |
Jahr Quelle: | 2012 |
Band/Heft Quelle: | 72(2012), 1, Seite 49-56 |
ISSN Quelle: | 1873-2402 |
Abstract: | BACKGROUND: Gene by environment (G×E) interaction between genetic variation in the promoter region of the serotonin transporter gene (serotonin transporter-linked polymorphic region [5-HTTLPR]) and stressful life events (SLEs) has been extensively studied in the context of depression. Recent findings suggest increased neural and endocrine stress sensitivity as a possible mechanism conveying elevated vulnerability to psychopathology. Furthermore, these G×E mediated alterations very likely reflect interrelated biological processes. METHODS: In the present functional magnetic resonance imaging study, amygdala reactivity to fearful stimuli was assessed in healthy male adults (n = 44), who were previously found to differ with regard to endocrine stress reactivity as a function of 5-HTTLPR × SLEs. Furthermore, functional connectivity between the amygdala and the hypothalamus was measured as a potential mechanism linking elevated neural and endocrine responses during stressful/threatening situations. The study sample was carefully preselected regarding 5-HTTLPR genotype and SLEs. RESULTS: We report significant G×E interaction on neural response patterns and functional amygdala-hypothalamus connectivity. Specifically, homozygous carriers of the 5-HTTLPR S' allele with a history of SLEs (S'S'/high SLEs group) displayed elevated bilateral amygdala activation in response to fearful faces. Within the same sample, a comparable G×E interaction effect has previously been demonstrated regarding increased cortisol reactivity, indicating a cross-validation of heightened biological stress sensitivity. Furthermore, S'S'/high SLEs subjects were characterized by an increased functional coupling between the right amygdala and the hypothalamus, thus indicating a potential link between neural and endocrine hyperreactivity. CONCLUSIONS: The present findings contribute to the ongoing debate on 5-HTTLPR × SLEs interaction and are discussed with respect to clinical implications. |
DOI: | doi:10.1016/j.biopsych.2012.01.030 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1016/j.biopsych.2012.01.030 |
| DOI: https://doi.org/10.1016/j.biopsych.2012.01.030 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Adult |
| Amygdala |
| Brain Mapping |
| Facial Expression |
| Fear |
| Gene-Environment Interaction |
| Humans |
| Hydrocortisone |
| Hypothalamus |
| Life Change Events |
| Magnetic Resonance Imaging |
| Male |
| Neural Pathways |
| Polymorphism, Genetic |
| Reference Values |
| Serotonin Plasma Membrane Transport Proteins |
| Stress, Psychological |
K10plus-PPN: | 1572237945 |
Verknüpfungen: | → Zeitschrift |
Interaction of the serotonin transporter-linked polymorphic region and environmental adversity / Alexander, Nina Carmen [VerfasserIn]; 12 March 2012 (Online-Ressource)
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