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Verfasst von:Alexander, Nina Carmen [VerfasserIn]   i
 Koppe, Georgia [VerfasserIn]   i
Titel:Interaction of the serotonin transporter-linked polymorphic region and environmental adversity
Titelzusatz:increased amygdala-hypothalamus connectivity as a potential mechanism linking neural and endocrine hyperreactivity
Verf.angabe:Nina Alexander, Tim Klucken, Georgia Koppe, Roman Osinsky, Bertram Walter, Dieter Vaitl, Gebhard Sammer, Rudolf Stark, and Juergen Hennig
E-Jahr:2012
Jahr:12 March 2012
Umfang:8 S.
Fussnoten:Gesehen am 23.04.2018
Titel Quelle:Enthalten in: Biological psychiatry
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1985
Jahr Quelle:2012
Band/Heft Quelle:72(2012), 1, Seite 49-56
ISSN Quelle:1873-2402
Abstract:BACKGROUND: Gene by environment (G×E) interaction between genetic variation in the promoter region of the serotonin transporter gene (serotonin transporter-linked polymorphic region [5-HTTLPR]) and stressful life events (SLEs) has been extensively studied in the context of depression. Recent findings suggest increased neural and endocrine stress sensitivity as a possible mechanism conveying elevated vulnerability to psychopathology. Furthermore, these G×E mediated alterations very likely reflect interrelated biological processes. METHODS: In the present functional magnetic resonance imaging study, amygdala reactivity to fearful stimuli was assessed in healthy male adults (n = 44), who were previously found to differ with regard to endocrine stress reactivity as a function of 5-HTTLPR × SLEs. Furthermore, functional connectivity between the amygdala and the hypothalamus was measured as a potential mechanism linking elevated neural and endocrine responses during stressful/threatening situations. The study sample was carefully preselected regarding 5-HTTLPR genotype and SLEs. RESULTS: We report significant G×E interaction on neural response patterns and functional amygdala-hypothalamus connectivity. Specifically, homozygous carriers of the 5-HTTLPR S' allele with a history of SLEs (S'S'/high SLEs group) displayed elevated bilateral amygdala activation in response to fearful faces. Within the same sample, a comparable G×E interaction effect has previously been demonstrated regarding increased cortisol reactivity, indicating a cross-validation of heightened biological stress sensitivity. Furthermore, S'S'/high SLEs subjects were characterized by an increased functional coupling between the right amygdala and the hypothalamus, thus indicating a potential link between neural and endocrine hyperreactivity. CONCLUSIONS: The present findings contribute to the ongoing debate on 5-HTTLPR × SLEs interaction and are discussed with respect to clinical implications.
DOI:doi:10.1016/j.biopsych.2012.01.030
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.biopsych.2012.01.030
 DOI: https://doi.org/10.1016/j.biopsych.2012.01.030
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adult
 Amygdala
 Brain Mapping
 Facial Expression
 Fear
 Gene-Environment Interaction
 Humans
 Hydrocortisone
 Hypothalamus
 Life Change Events
 Magnetic Resonance Imaging
 Male
 Neural Pathways
 Polymorphism, Genetic
 Reference Values
 Serotonin Plasma Membrane Transport Proteins
 Stress, Psychological
K10plus-PPN:1572237945
Verknüpfungen:→ Zeitschrift

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