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| Titel: | Synchronizing nuclear import of ribosomal proteins with ribosome assembly |
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| Mitwirkende: | Kressler, Dieter [VerfasserIn]  |
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| | Bange, Gert [VerfasserIn] |
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| | Stjepanović, Goran [VerfasserIn] |
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| | Bradatsch, Bettina [VerfasserIn] |
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| | Strauß, Daniela [VerfasserIn] |
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| | Sinning, Irmgard [VerfasserIn] |
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| | Hurt, Ed [VerfasserIn] |
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| Verf.angabe: | Dieter Kressler, Gert Bange, Yutaka Ogawa, Goran Stjepanovic, Bettina Bradatsch, Dagmar Pratte, Stefan Amlacher, Daniela Strauß, Yoshihiro Yoneda, Jun Katahira, Irmgard Sinning, Ed Hurt |
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| E-Jahr: | 2012 |
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| Jahr: | 2 November 2012 |
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| Umfang: | 6 S. |
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| Fussnoten: | Gesehen am 25.04.2018 |
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| Titel Quelle: | Enthalten in: Science |
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| Ort Quelle: | Washington, DC : American Association for the Advancement of Science, 1880 |
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| Jahr Quelle: | 2012 |
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| Band/Heft Quelle: | 338(2012), 6107, Seite 666-671 |
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| ISSN Quelle: | 1095-9203 |
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| Abstract: | Ribosomal proteins are synthesized in the cytoplasm, before nuclear import and assembly with ribosomal RNA (rRNA). Little is known about coordination of nucleocytoplasmic transport with ribosome assembly. Here, we identify a transport adaptor, symportin 1 (Syo1), that facilitates synchronized coimport of the two 5S-rRNA binding proteins Rpl5 and Rpl11. In vitro studies revealed that Syo1 concomitantly binds Rpl5-Rpl11 and furthermore recruits the import receptor Kap104. The Syo1-Rpl5-Rpl11 import complex is released from Kap104 by RanGTP and can be directly transferred onto the 5S rRNA. Syo1 can shuttle back to the cytoplasm by interaction with phenylalanine-glycine nucleoporins. X-ray crystallography uncovered how the α-solenoid symportin accommodates the Rpl5 amino terminus, normally bound to 5S rRNA, in an extended groove. Symportin-mediated coimport of Rpl5-Rpl11 could ensure coordinated and stoichiometric incorporation of these proteins into pre-60S ribosomes. |
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| DOI: | doi:10.1126/science.1226960 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei registrierungspflichtig: Volltext: https://doi.org/10.1126/science.1226960 |
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| | kostenfrei registrierungspflichtig: Volltext: http://science.sciencemag.org/content/338/6107/666.full |
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| | DOI: https://doi.org/10.1126/science.1226960 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Bibliogr. Hinweis: | Erscheint auch als : Druck-Ausgabe: Synchronizing nuclear import of ribosomal proteins with ribosome assembly. - 2012 |
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| Sach-SW: | Active Transport, Cell Nucleus |
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| | Amino Acid Sequence |
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| | Base Sequence |
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| | beta Karyopherins |
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| | Cell Nucleus |
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| | Chaetomium |
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| | Crystallography, X-Ray |
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| | Fungal Proteins |
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| | Models, Molecular |
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| | Molecular Sequence Data |
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| | Protein Binding |
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| | Protein Conformation |
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| | Protein Multimerization |
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| | Protein Structure, Tertiary |
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| | Ribosomal Proteins |
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| | Ribosomes |
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| | RNA-Binding Proteins |
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| | RNA, Fungal |
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| | RNA, Ribosomal, 5S |
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| | Saccharomyces cerevisiae |
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| K10plus-PPN: | 1572343532 |
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| Verknüpfungen: | → Zeitschrift |
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Synchronizing nuclear import of ribosomal proteins with ribosome assembly / Kressler, Dieter [VerfasserIn]; 2 November 2012 (Online-Ressource)
