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Verfasst von:Coughlin, Jennifer M. [VerfasserIn]   i
 Leweke, F. Markus [VerfasserIn]   i
Titel:Reduced superoxide dismutase-1 (SOD1) in cerebrospinal fluid of patients with early psychosis in association with clinical features
Verf.angabe:Jennifer M. Coughlin, M.D.; Lindsay N. Hayes, Ph.D.; Teppei Tanaka, M.D.; Meifang Xiao, Ph.D.; Robert H. Yolken, M.D.; Paul Worley, M.D.; F. Markus Leweke, M.D.; Akira Sawa, M.D., Ph.D.
E-Jahr:2017
Jahr:May 2017
Umfang:6 S.
Fussnoten:Gesehen am 25.04.2018
Titel Quelle:Enthalten in: Schizophrenia research
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1988
Jahr Quelle:2017
Band/Heft Quelle:183(2017), Seite 64-69
ISSN Quelle:1573-2509
Abstract:Oxidative stress is implicated in the underlying pathophysiology of psychosis from studies of animal models and of tissues obtained from patients. Superoxide dismutase 1 (SOD1) is an antioxidant responsible for reducing free radicals. SOD1 levels in cerebrospinal fluid (CSF) reportedly correlate with those in brain. We hypothesized that patients in early-stages of psychotic disease may have altered SOD1 in CSF compared to healthy controls. We previously reported in a pilot study that SOD1 levels in CSF of patients with recent onset schizophrenia (SZ) were lower compared to healthy controls. Building on that work, in the present study we examined SOD1 levels in CSF acquired from two additional cohorts. Specifically, we studied SOD1 levels in CSF from a cohort of 15 patients with recent-onset psychosis and 18 healthy controls, as well as the second cohort of 18 antipsychotic-naïve patients with SZ and 20 healthy controls. In the first cohort, recent onset of illness was defined as within five years of onset of psychotic symptoms, and performance on neuropsychological testing as well as symptom severity were assessed. We observed 26.5% lower SOD1 in CSF from patients across both cohorts compared to controls (P=0.045) that was consistent with our previous report (30%). Among the cohort of patients with recent onset of SZ, SOD1 in CSF was positively correlated with composite performance on neuropsychological testing. Our results support further study of the relationship between cognitive deficits and oxidative stress in the central nervous system of patients with psychosis, including through study of SOD1.
DOI:doi:10.1016/j.schres.2016.10.040
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.schres.2016.10.040
 Volltext: http://www.sciencedirect.com/science/article/pii/S0920996416304923
 DOI: https://doi.org/10.1016/j.schres.2016.10.040
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cognition
 Cerebrospinal fluid (CSF)
 Oxidative stress
 Psychosis
 Superoxide dismutase 1 (SOD1)
K10plus-PPN:1572348038
Verknüpfungen:→ Zeitschrift

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