Ruthenium-catalyzed deaminative hydrogenation of aliphatic and aromatic nitriles to primary alcohols

• Verfasst von: Molnár, István G. [VerfasserIn]
• Verfasst von: Calleja Ramos, Pilar [VerfasserIn]
• Verfasst von: Hashmi, A. Stephen K. [VerfasserIn]
• Verfasst von: Schaub, Thomas [VerfasserIn]
• Titel: Ruthenium-catalyzed deaminative hydrogenation of aliphatic and aromatic nitriles to primary alcohols
• Verf.angabe: István Gábor Molnár, Pilar Calleja, Martin Ernst, A. Stephen K. Hashmi, Thomas Schaub
• E-Jahr: 2017
• Jahr: 4 July 2017
• Umfang: 4 S.
• Fussnoten: Gesehen am 25.04.2018
• Titel Quelle: Enthalten in: ChemCatChem
• Ort Quelle: Weinheim : Wiley-VCH, 2009
• Jahr Quelle: 2017
• Band/Heft Quelle: 9(2017), 22, Seite 4175-4178
• ISSN Quelle: 1867-3899
• DOI: doi:10.1002/cctc.201700878
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: alcohols
• Sach-SW: deamination
• Sach-SW: hydrogenation
• Sach-SW: nitriles
• Sach-SW: ruthenium
• K10plus-PPN: 1572352906

Abstract

The deaminative hydrogenation of nitriles towards alcohols is a useful reaction to transform nitriles into alcohols with NH3 as the sole byproduct. Using the simple and robust RuHCl(CO)(PPh3)3 complex as a catalyst, at low H2 pressures a series of aliphatic and aromatic nitriles could be transformed into the corresponding alcohols. Suitable solvent systems for these reactions were 1,4-dioxane/water and EtOH/water mixtures. In most cases, the selectivity for the alcohols was excellent, and the corresponding amines were formed only in trace amounts.