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Verfasst von:Hauser, Tobias U. [VerfasserIn]   i
 Brandeis, Daniel [VerfasserIn]   i
Titel:Increased fronto-striatal reward prediction errors moderate decision making in obsessive-compulsive disorder
Verf.angabe:T.U. Hauser, R. Iannaccone, R.J. Dolan, J. Ball, J. Hättenschwiler, R. Drechsler, M. Rufer, D. Brandeis, S. Walitza and S. Brem
E-Jahr:2017
Jahr:09 January 2017
Umfang:13 S.
Fussnoten:Gesehen am 25.04.2018
Titel Quelle:Enthalten in: Psychological medicine
Ort Quelle:Cambridge : Cambridge University Press, 1970
Jahr Quelle:2017
Band/Heft Quelle:47(2017), 7, Seite 1246-1258
ISSN Quelle:1469-8978
Abstract:Background: Obsessive-compulsive disorder (OCD) has been linked to functional abnormalities in fronto-striatal networks as well as impairments in decision making and learning. Little is known about the neurocognitive mechanisms causing these decision-making and learning deficits in OCD, and how they relate to dysfunction in fronto-striatal networks. Method: We investigated neural mechanisms of decision making in OCD patients, including early and late onset of disorder, in terms of reward prediction errors (RPEs) using functional magnetic resonance imaging. RPEs index a mismatch between expected and received outcomes, encoded by the dopaminergic system, and are known to drive learning and decision making in humans and animals. We used reinforcement learning models and RPE signals to infer the learning mechanisms and to compare behavioural parameters and neural RPE responses of the OCD patients with those of healthy matched controls. Results: Patients with OCD showed significantly increased RPE responses in the anterior cingulate cortex (ACC) and the putamen compared with controls. OCD patients also had a significantly lower perseveration parameter than controls. Conclusions: Enhanced RPE signals in the ACC and putamen extend previous findings of fronto-striatal deficits in OCD. These abnormally strong RPEs suggest a hyper-responsive learning network in patients with OCD, which might explain their indecisiveness and intolerance of uncertainty.
DOI:doi:10.1017/S0033291716003305
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1017/S0033291716003305
 Volltext: https://www-cambridge-org.ezproxy.medma.uni-heidelberg.de/core/journals/psychological-medicine/article/increased-frontos ...
 DOI: https://doi.org/10.1017/S0033291716003305
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Age of onset
 anterior cingulate cortex
 obsessive-compulsive disorder
 reinforcement learning
 reward prediction errors
K10plus-PPN:1572369817
Verknüpfungen:→ Zeitschrift

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