Calycophyllum spruceanum (Benth.), the Amazonian “tree of youth” prolongs longevity and enhances stress resistance in Caenorhabditis elegans

• Verfasst von: Peixoto, Herbenya [VerfasserIn]
• Verfasst von: Roxo, Mariana [VerfasserIn]
• Verfasst von: Braun, Markus S. [VerfasserIn]
• Verfasst von: Wang, Xiaojuan [VerfasserIn]
• Verfasst von: Wink, Michael [VerfasserIn]
• Titel: Calycophyllum spruceanum (Benth.), the Amazonian “tree of youth” prolongs longevity and enhances stress resistance in Caenorhabditis elegans
• Verf.angabe: Herbenya Peixoto, Mariana Roxo, Hector Koolen, Felipe da Silva, Emerson Silva, Markus Santhosh Braun, Xiaojuan Wang and Michael Wink
• E-Jahr: 2018
• Jahr: 27 February 2018
• Umfang: 15 S.
• Teil: volume:23
• Teil: year:2018
• Teil: number:3
• Teil: extent:15
• Fussnoten: Gesehen am 26.04.2018
• Titel Quelle: Enthalten in: Molecules
• Ort Quelle: Basel : MDPI, 1996
• Jahr Quelle: 2018
• Band/Heft Quelle: 23(2018,3) Artikel-Nummer 534, 15 Seiten
• ISSN Quelle: 1420-3049
• DOI: doi:10.3390/molecules23030534
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: <i>Caenorhabditis elegans</i>
• Sach-SW: <i>Calycophyllum spruceanum</i>
• Sach-SW: aging
• Sach-SW: antioxidants
• Sach-SW: oxidative stress
• K10plus-PPN: 1572423870
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

The tree popularly known in Brazil as mulateiro or pau-mulato (Calycophyllum spruceanum (Benth.) K. Schum.) is deeply embedded in the herbal medicine of the Amazon region. Different preparations of the bark are claimed to have anti-aging, antioxidant, antimicrobial, emollient, wound healing, hemostatic, contraceptive, stimulant, and anti-diabetic properties. The current study aims to provide the first step towards a science-based evidence of the beneficial effects of C. spruceanum in the promotion of longevity and in the modulation of age-related markers. For this investigation, we used the model system Caenorhabditis elegans to evaluate in vivo antioxidant and anti-aging activity of a water extract from C. spruceanum. To chemically characterize the extract, HPLC MS (High Performance Liquid Chromatography Mass Spectrometry)/MS analyses were performed. Five secondary metabolites were identified in the extract, namely gardenoside, 5-hydroxymorin, cyanidin, taxifolin, and 5-hydroxy-6-methoxycoumarin-7-glucoside. C. spruceanum extract was able to enhance stress resistance and to extend lifespan along with attenuation of aging-associated markers in C. elegans. The demonstrated bioactivities apparently depend on the DAF-16/FOXO pathway. The data might support the popular claims of mulateiro as the “tree of youth”, however more studies are needed to clarify its putative benefits to human health.