| |  Online-Ressource |
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| Verfasst von: | Thomann, Philipp [VerfasserIn]  |
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| | Nolte, Henrike Maria [VerfasserIn] |
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| | Hirjak, Dusan [VerfasserIn] |
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| | Hofer, Stefan [VerfasserIn] |
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| | Seidl, Ulrich [VerfasserIn] |
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| | Depping, Malte S. [VerfasserIn] |
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| | Maier-Hein, Klaus H. [VerfasserIn] |
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| Titel: | Neuromodulation in response to electroconvulsive therapy in schizophrenia and major depression |
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| Verf.angabe: | Philipp Arthur Thomann, Robert Christian Wolf, Henrike Maria Nolte, Dusan Hirjak, Stefan Hofer, Ulrich Seidl, Malte Sebastian Depping, Bram Stieltjes, Klaus Maier-Hein, Fabio Sambataro, Torsten Wüstenberg |
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| E-Jahr: | 2017 |
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| Jahr: | 16 January 2017 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 26.04.2018 |
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| Titel Quelle: | Enthalten in: Brain stimulation |
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| Ort Quelle: | New York, NY [u.a.] : Elsevier, 2008 |
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| Jahr Quelle: | 2017 |
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| Band/Heft Quelle: | 10(2017), 3, Seite 637-644 |
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| ISSN Quelle: | 1876-4754 |
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| Abstract: | Background: Electroconvulsive therapy (ECT) is one of the most effective treatments in severe and treatment- resistant major depressive disorder (MDD). ECT has been also shown to be effective in schizophrenia (SZ), particularly when rapid symptom reduction is needed or in cases of resistance to drug-treatment. However, its precise mechanisms of action remain largely unknown. Objective/Hypothesis: This study examined whether ECT exerts disorder-specific or unspecific modulation of brain structure and function in SZ and MDD. Methods: We investigated neuromodulatory effects of right-sided unilateral ECT in pharmacoresistant patients with SZ or MDD. Magnetic resonance imaging was conducted before and after ECT to investigate treatment- related effects on brain structure and function. Imaging data were analyzed by means of Voxel Based Morphometry and Resting State Functional Connectivity (RSFC) methods. Results: Right unilateral ECT induced transdiagnostic regional increases of limbic gray matter and modulations of neural coupling at rest. Structural effects were accompanied by a decrease in RSFC within temporoparietal, prefrontal and cortical midline structures, and an increase in hypothalamic RSFC. The extent of structural and functional change was partially inversely associated with the baseline measures. Conclusion: The present findings provide first evidence for transdiagnostic changes of brain structure together with modulation of brain function after ECT. The data indicate diagnosis-unspecific mechanisms of action with respect to regional gray matter volume and resting-state functional connectivity. |
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| DOI: | doi:10.1016/j.brs.2017.01.578 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1016/j.brs.2017.01.578 |
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| | DOI: https://doi.org/10.1016/j.brs.2017.01.578 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | adrenal axis function |
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| | cell-proliferation |
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| | connectivity |
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| | cortical thickness |
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| | disorder |
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| | Electroconvulsive therapy |
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| | hippocampal volume |
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| | human hypothalamus |
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| | Magnetic resonance imaging |
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| | Major depression |
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| | metaanalysis |
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| | Schizophrenia |
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| | sex-differences |
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| | state functional mri |
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| K10plus-PPN: | 1572408103 |
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| Verknüpfungen: | → Zeitschrift |
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Neuromodulation in response to electroconvulsive therapy in schizophrenia and major depression / Thomann, Philipp [VerfasserIn]; 16 January 2017 (Online-Ressource)
