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Status: Bibliographieeintrag

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Verfasst von:Luís, Catarina [VerfasserIn]   i
 Spanagel, Rainer [VerfasserIn]   i
 Koehr, Georg [VerfasserIn]   i
Titel:Persistent strengthening of the prefrontal cortex
Titelzusatz:nucleus accumbens pathway during incubation of cocaine-seeking behavior
Verf.angabe:Catarina Luís, Nazzareno Cannella, Rainer Spanagel, Georg Köhr
E-Jahr:2017
Jahr:February 2017
Umfang:10 S.
Fussnoten:Gesehen am 26.04.2018
Titel Quelle:Enthalten in: Neurobiology of learning and memory
Ort Quelle:Orlando, Fla. : Academic Press, 1995
Jahr Quelle:2017
Band/Heft Quelle:138(2017), Seite 281-290
ISSN Quelle:1095-9564
Abstract:High rates of relapse after prolonged abstinence are often triggered by exposure to drug-associated cues that induce drug craving. Incubation of drug craving is a phenomenon that consists of time-dependent increases in cue-induced drug craving during withdrawal. Plasticity mechanisms in the nucleus accumbens (NAc) underlie drug-seeking responses and involve changes in excitatory synaptic transmission’s efficacy. In particular, the prefrontal cortex (PFC) glutamatergic input to the NAc core has been well characterized regarding cocaine-evoked plasticity following non-contingent versus contingent exposure to cocaine or alternatively after protracted abstinence. Still, the synaptic strength during the course of withdrawal compared to drug-naïve condition is unknown, since electrophysiological characterizations are mainly performed in brain slices or focus on distinct time points during cocaine-evoked plasticity in vivo. Here we used an incubation paradigm, in which rats had extended accessed to cocaine self-administration, and underwent cue-induced reinstatement at withdrawal day 1 and 30. Longitudinal in vivo field potential recordings in awake rats showed that chronic contingent exposure to cocaine strengthened the prelimbic PFC to NAc core pathway when compared to pre-cocaine condition. This strengthening was associated with decreased paired-pulse ratios (PPR), indicative of presynaptic enhancement of glutamate release, which persisted throughout withdrawal. Moreover, both field potential increase and PPR reduction after chronic cocaine exposure correlated with the number of cocaine infusions received during training. The present results together with previous findings of withdrawal-dependent postsynaptic enhancement of the PFC-NAc core pathway, suggest an additional presynaptic strengthening that is initiated during self-administration and maintained throughout abstinence in drug-seeking rats. These cocaine-driven neuroadaptations may provide a neural substrate for maladaptive processing of cues that can ultimately trigger craving and relapse.
DOI:doi:10.1016/j.nlm.2016.10.003
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1016/j.nlm.2016.10.003
 Volltext: http://www.sciencedirect.com/science/article/pii/S1074742716302441
 DOI: https://doi.org/10.1016/j.nlm.2016.10.003
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cocaine self-administration
 electrophysiology
 Field potential
 Paired-pulse ratio
 Presynaptic glutamate
 Reinstatement
K10plus-PPN:1572420634
Verknüpfungen:→ Zeitschrift

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