Population-level decline in BMI and systolic blood pressure following mass HIV treatment

• Verfasst von: Geldsetzer, Pascal [VerfasserIn]
• Verfasst von: Bärnighausen, Till [VerfasserIn]
• Titel: Population-level decline in BMI and systolic blood pressure following mass HIV treatment
• Titelzusatz: evidence from rural KwaZulu-Natal
• Verf.angabe: Pascal Geldsetzer, Andrea B. Feigl, Frank Tanser, Dickman Gareta, Deenan Pillay, and Till Bärnighausen
• Jahr des Originals: 2016
• Umfang: 7 S.
• Fussnoten: Published: 7 December 2016 ; Gesehen am 02.05.2018
• Titel Quelle: Enthalten in: Obesity
• Jahr Quelle: 2017
• Band/Heft Quelle: 25(2017), 1, S. 200-206
• ISSN Quelle: 1930-739X
• DOI: doi:10.1002/oby.21663
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1572507055

Abstract

Objective Clinic-based studies have shown that patients with human immunodeficiency virus (HIV) gain weight after initiation of antiretroviral therapy (ART). This study aimed to determine whether the scale-up of ART was associated with a population-level increase in body mass index (BMI) and blood pressure (BP) in a community with high HIV and obesity prevalence. Methods A household survey was conducted in rural KwaZulu-Natal before ART scale-up (in 2004) and when ART coverage had reached 25% (in 2010). Anthropometric data was linked with HIV surveillance data. Results Mean BMI decreased in women from 29.9 to 29.1 kg/m2 (P = 0.002) and in men from 24.2 to 23.0 kg/m2 (P < 0.001). Similarly, overweight and obesity prevalence declined significantly in both sexes. Mean systolic BP decreased from 123.0 to 118.2 mm Hg (P < 0.001) among women and 128.4 to 123.2 mm Hg (P < 0·001) among men. Conclusions Large-scale ART provision is likely to have caused a decline in BMI at the population level, because ART has improved the survival of those with substantial HIV-related weight loss. The ART scale-up may have created an unexpected opportunity to sustain population-level weight loss in communities with high HIV and obesity prevalence though targeted lifestyle and nutrition interventions.